|
rs1049550
|
|
|
0.770 |
GeneticVariation |
BEFREE |
''C'' allele of SNP rs1049550 may be a risk factor for sarcoidosis in overall population.
|
27537711 |
2016 |
|
rs2296283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sarcoidosis, in general, was significantly associated with three SNPs in the VEGFR-1 gene: rs7337610 (P = .041), rs2296283 (P = .034), and rs12858139 (P = .027).
|
19741061 |
2010 |
|
rs12858139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sarcoidosis, in general, was significantly associated with three SNPs in the VEGFR-1 gene: rs7337610 (P = .041), rs2296283 (P = .034), and rs12858139 (P = .027).
|
19741061 |
2010 |
|
rs1049550
|
|
|
0.770 |
GeneticVariation |
BEFREE |
A common nonsynonymous SNP (rs1049550, C > T, [corrected] R230C) was found to be strongly associated with sarcoidosis.
|
19165924 |
2008 |
|
rs479777
|
|
|
0.810 |
GeneticVariation |
GWASDB |
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
|
22837380 |
2012 |
|
rs479777
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1.
|
22837380 |
2012 |
|
rs2075800
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A strong association was found between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis.
|
17591867 |
2007 |
|
rs61860052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for rs1049550, two additional novel ANXA11 sarcoidosis associations were identified only in African Americans--rs61860052 (odds ratio (OR)=0.62; 95% confidence interval (CI)=0.40-0.97) and rs4377299 (OR=1.31; 95% CI=1.06-1.63).
|
23151485 |
2013 |
|
rs4377299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for rs1049550, two additional novel ANXA11 sarcoidosis associations were identified only in African Americans--rs61860052 (odds ratio (OR)=0.62; 95% confidence interval (CI)=0.40-0.97) and rs4377299 (OR=1.31; 95% CI=1.06-1.63).
|
23151485 |
2013 |
|
rs748009686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, an IFNA17 polymorphism (551T-->G) was found to be associated with susceptibility to sarcoidosis (odds ratio 3.27 [95% CI: 1.44-7.46], P=0.004, P(c)=0.04), but not to tuberculosis.
|
15004750 |
2004 |
|
rs9298814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, an IFNA17 polymorphism (551T-->G) was found to be associated with susceptibility to sarcoidosis (odds ratio 3.27 [95% CI: 1.44-7.46], P=0.004, P(c)=0.04), but not to tuberculosis.
|
15004750 |
2004 |
|
rs1800076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although R75Q was present in seven families, it was neither associated with the sarcoidosis phenotype in the German population (P=0.5), nor was it linked to sarcoidosis (P=0.54).
|
12404105 |
2002 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Although rs2076530</span> was not associated with sarcoidosis in either African American sample, a three-locus haplotype that included rs2076530 was associated with sarcoidosis across all three study samples.
|
16080124 |
2005 |
|
rs1462906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the eight other markers that demonstrated suggestive ancestry associations with sarcoidosis were rs1462906 on chromosome 8p12, which had the most significant association with European ancestry (aRR=0.65; P=0.002), and markers on chromosomes 5p13 (aRR=1.46; P=0.005) and 5q31 (aRR=0.67; P=0.005), which correspond to regions we previously identified through sib-pair linkage analyses.
|
21179114 |
2011 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
BEFREE |
An association has been reported between sarcoidosis and a single nucleotide polymorphism in BTNL2, rs2076530, also termed the A allele.
|
21410903 |
2011 |
|
rs1049550
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Annexin A11 gene polymorphism (R230C variant) and sarcoidosis in a Portuguese population.
|
24032725 |
2013 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
BEFREE |
As BTNL2 (butyrophilin-like 2) gene polymorphism was found linked with the susceptibility to sarcoidosis, we investigated whether a specific genotype of BTNL2 gene G16071A (or rs2076530) single-nucleotide polymorphism (SNP) would be associated with the risk of sarcoid uveitis in all patient subgroups.
|
30872286 |
2019 |
|
rs3817963
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Both BTNL2 SNPs were associated with risk of sarcoidosis in separate models, but in a combined analysis the increased risk was due to the A-allele of the rs3817963 SNP; each copy of the A-allele was associated with a 40 % increase in risk of sarcoidosis (p = 0.02) and was confirmed by our haplotypic analysis.
|
23543185 |
2013 |
|
rs206530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03.
|
23017494 |
2012 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
BEFREE |
But, no significant association was detected between any of the polymorphisms investigated and TB, including rs2076530 SNP that was previously found to be associated with sarcoidosis.
|
20176143 |
2010 |
|
rs1883832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
rs3177928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs were associated with sarcoidosis disease course (the strongest association with rs3177928, <i>P</i> = 0.003, OR = 1.9).
|
28469621 |
2017 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
|
22936702 |
2013 |
|
rs2076530
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
|
22936702 |
2013 |
|
rs1953600
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
|
22936702 |
2013 |