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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/cortical thickness/cortical surface area in 150 first-episode treatment-naïve patients with schizophrenia and 100 healthy controls.
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25564193 |
2015 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism of the catechol-O-methyltransferase (COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity.
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26255563 |
2015 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
The Pakistani population with Val158Met SNP showed more susceptibility towards developing schizophrenia.
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25801838 |
2015 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia.
|
25600541 |
2015 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we analyzed the interaction between pharmacological treatment (clozapine vs typical/atypical D2 blockers) and COMT rs4680 polymorphism on cognitive changes after cognitive remediation therapy, in a sample of 98 clinically stabilized patients with schizophrenia.
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24656901 |
2014 |
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rs4680
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|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the possible epigenetic modulation of the expression of the COMT Val(158)Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.
|
24252819 |
2014 |
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rs4680
|
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0.100 |
GeneticVariation |
BEFREE |
We found a significant association of the COMT Va</span>l(158)Met polymorphism with schizophrenia</span>.
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24782165 |
2014 |
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rs4680
|
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0.100 |
GeneticVariation |
BEFREE |
We aimed to examine personality traits of remitted patients with schizophrenia as compared to symptomatic patients and healthy controls and to investigate whether the COMT Val158Met polymorphism influences their personality.
|
24888672 |
2014 |
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rs4680
|
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0.100 |
GeneticVariation |
BEFREE |
We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD2) G-T (rs2283265) single nucleotide polymorphisms and functional magnetic resonance imaging during an emotional response inhibition test in 43 healthy adults and 27 people with schizophrenia to determine the extent to which COMT Val108/158Met and DRD2 G-T polymorphisms combine to influence prefrontal response to cognitive-affective challenges.
|
24495967 |
2014 |
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rs165599
|
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0.100 |
GeneticVariation |
BEFREE |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
|
23598060 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
|
23598060 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
It is possible that the COMT Val(158)Met polymorphism therefore contributes to the development of these neuropsychological and brain structural endophenotypes of schizophrenia, in which the prefrontal cortex may represent the neural substrate underlying both n-back and CPT performances.
|
23527885 |
2013 |
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rs4680
|
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0.100 |
GeneticVariation |
BEFREE |
We employed a one-way analysis of variance (ANOVA) and a multiple regression analysis to determine the associations between the COMT Val158Met genotype and the BACS-J measurements.
|
24282499 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
This is the first study of the effect of rs4680 on interpersonal distress and neural correlates of empathy in schizophrenia.
|
22901597 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli.
|
22617427 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
Eight SNPs were nominally associated with SZ in either case-control or family based analyses (p < 0.05, rs7631540 and rs2046496 in DRD3; rs363399 and rs10082463 in SLC18A2; rs4680, rs4646315 and rs9332377 in COMT). rs6271 at DBH was associated in both analyses.
|
23932573 |
2013 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia.
|
23353103 |
2013 |
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rs165599
|
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|
0.100 |
GeneticVariation |
BEFREE |
Thus, in the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene.
|
23295417 |
2012 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met catechol-O-methyl transferase functional polymorphism has been repeatedly associated to differences in performing the Wisconsin Card Sorting Test in both, patients with schizophrenia and healthy individuals.
|
21934644 |
2012 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our results confirm that COMT is a good candidate for schizophrenia risk, by replicating the association with rs4680 and identifying a novel SNP association.
|
20934310 |
2012 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.
|
22905266 |
2012 |
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rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
These data indicate that odor identification impairments observed in schizophrenia are influenced by the COMT val158met polymorphism.
|
22148860 |
2012 |
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rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no association of rs4680 with SZ in the combined sample (n=4071, p=0.110, odds ratio=1.08).
|
22963606 |
2012 |
|
rs4680
|
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|
0.100 |
GeneticVariation |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
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rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MEDLINE search (12/31/11) yielded 14 studies examining the association of the COMT gene polymorphism (rs4680) and aggression in schizophrenia (total n=2219).
|
22784685 |
2012 |