|
rs1554162524
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Six haplotype-tagging SNPs in the TLR4 gene were subsequently examined to analyze their influence on TLR4 A896G SNPs relationship to sepsis severity.
|
19131814 |
2009 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To investigate whether the presence of the TLR4(D299G) mutation may correlate with the development or outcome of sepsis following major visceral surgery the presence of TLR4(D299G) mutation was analysed in 307 Caucasian patients (154 without and 153 with sepsis).
|
12807489 |
2003 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The odds ratio for the association of Asp299Gly polymorphism with sepsis</span> risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57).
|
22537674 |
2012 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models.
|
27958344 |
2016 |
|
rs4986790
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found no significant association for either the polymorphism rs4986790 or rs4986791 with sepsis susceptibility in total analysis under any genetic models.
|
27958344 |
2016 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The odds ratio for the association of Asp299Gly polymorphism with sepsis risk was 1.22 (95% CI: 0.90-1.65, P=0.21), and the association of Thr399Ile</span> polymorphism was 1.16 (95%CI: 0.70-1.91, P=0.57).
|
22537674 |
2012 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
|
rs4986791
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)).
|
18434886 |
2008 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population.
|
29340067 |
2017 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The minor allele frequency of rs1800629 was significantly higher in severe sepsis patients than that in both healthy controls (P(adj) = 0.00046, odds ratio (OR)(adj) = 1.92) and sepsis patients (P(adj) = 0.002, OR(adj) = 1.56).
|
23029405 |
2012 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10.
|
27592234 |
2016 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs.
|
25239655 |
2014 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) -786T→C and 894G→T polymorphisms have been associated with eNOS dysfunction, which might further compromise microcirculatory blood flow during sepsis and increase the risk of organ injury.
|
21336191 |
2011 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored.
|
18827745 |
2009 |