|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development.
|
28472164 |
2017 |
|
rs1043210477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evaluating the subgroup of 293 ICU patients with sepsis, a pooled analysis including two genetic variants GPx1 and SOD2 (47C>T SNP, rs4880; protein variant in MnSOD: Ala-9Val) showed a significant difference in relation to progression to septic shock.
|
25497738 |
2015 |
|
rs1045411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The HMGB1 gene rs2249825 and rs1045411</span> site SNPs are associated with susceptibility and outcomes of Chinese Han patients with sepsis.
|
30423384 |
2019 |
|
rs10506481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas IRAK3 SNPs were not associated with susceptibility to severe sepsis, rs10506481 showed a significant association with the development of ALI among patients with sepsis (P = 0.007).
|
21297081 |
2011 |
|
rs1061170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Homozygosity for the complement factor H Y402H polymorphism, which is thought to reduce complement inhibition, was associated with less frequent SIRS/sepsis (the adjusted odds ratio for the homozygous variant complement factor H Y402H [CC] carriers was 0.3, 95% confidence interval, 0.1-0.7, p = .005).
|
20351616 |
2010 |
|
rs1061170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
rs1065489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
rs10865710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10865710 polymorphism in the PPARγ gene might be used to assess the risk of sepsis and multiple organ dysfunction syndrome (MODS) in trauma patients.
|
27023591 |
2016 |
|
rs11137480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of limited sample size, conclusive findings could not be drawn in African-descent ARDS subjects; however, significant associations were found for two promoter SNPs (rs7022797 -1899T/G; rs11137480 -1785G/C), across two ED samples supporting the association of alleles -1899G and -1785C with decreased risk for sepsis-associated ARDS.
|
23911438 |
2013 |
|
rs11216153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively) and in the sepsis alone patients (58.2%, 78.4%, respectively).
|
24885977 |
2014 |
|
rs1126647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The male population carrying the homozygote TT genotype and T allele of rs4073, the homozygote CC genotype and C allele of rs2227306 and homozygote AA genotype and A allele of rs1126647 are more susceptible to sepsis, suggesting there is a protective effect in females carrying these genotypes and alleles respectively.
|
27642120 |
2016 |
|
rs1129055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD86 gene polymorphisms rs1129055 and rs1915087 may increase the risk of sepsis.
|
30343689 |
2018 |
|
rs1129055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Nevertheless, rs2715267 had no significant association with sepsis susceptibility (P > .05).AA genotype and A allele of CD86 polymorphism rs1129055 might be correlated with decreased sepsis susceptibility in Chinese Han population, but not rs2715267.
|
31651850 |
2019 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were no significant associations between either IL-1B-511 (rs16944) or IL-1B-31 (rs1143627) and sepsis susceptibility in overall or subgroup analyses.
|
24428862 |
2014 |
|
rs1143634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a cross-sectional study to genotype 415 septic patients and 205 patients without sepsis for the SNPs -308(G/A) rs1800629 of TNF; +252 (G/A) rs909253 of LTA; -511(A/G) rs16944 and +3953(C/T) rs1143634 of IL1B; and -1082(A/G) rs1800896, -819(C/T) rs1800871 and -592(C/A) rs1800872 of IL10.
|
27592234 |
2016 |
|
rs1143643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both).
|
25000179 |
2014 |
|
rs11465996
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, only the rs11465996 polymorphism was shown to be significantly associated with higher sepsis morbidity rate and MOD scores in patients with major trauma in both Chongqing and Zhejiang districts.
|
22266968 |
2012 |
|
rs11536889
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.
|
25394369 |
2014 |
|
rs11536889
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results offer the first evidence that TLR4 rs11536889 is a useful marker of organ failure in patients with sepsis.
|
24950711 |
2014 |
|
rs1153879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) of TLR4 (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) and CD14 (rs2569190 and rs2563298) in patients with sepsis and control subjects in the Guangxi Province were analyzed by using the polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing methods.
|
25394369 |
2014 |
|
rs11568821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data provide first associative evidence for PD-1 rs11568821 as a prognostic indicator in patients with sepsis.
|
24463978 |
2014 |
|
rs11666254
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11666254 polymorphism in the FPR2/ALX gene is a functional SNP that increases sepsis susceptibility in patients after traumatic injury.
|
28679406 |
2017 |
|
rs11684747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls).
|
27607600 |
2016 |
|
rs11689958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls).
|
27607600 |
2016 |
|
rs12048215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs2027432 and rs12048215 polymorphisms might be used as relevant risk estimates for the development of sepsis and MOD syndrome in patients with major trauma, in which rs2027432 might be a functional SNP.
|
22112657 |
2011 |