|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provides valuable clinical evidence that the MCP-1/CCL2 polymorphisms rs1024611 and rs2857656 are associated with sepsis susceptibility and development.
|
28472164 |
2017 |
|
rs1429638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1429638 polymorphism in the CXCL1 gene and the rs2297630 polymorphism in the CXCL12 gene were associated with altered susceptibility to sepsis and might be used as important genetic markers to assess the risks of sepsis in trauma patients.
|
30489503 |
2019 |
|
rs1891320
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis.
|
20463618 |
2010 |
|
rs2808630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
rs352162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR9 polymorphisms rs187084 and rs352162 might be used to provide relevant risk estimates for the development of sepsis and MOD in patients with major trauma.
|
21633947 |
2011 |
|
rs653765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Clinical data showed that the rs653765 G→A polymorphism was positively correlated with the development of sepsis, as evidenced by a multiple-center case-control association study with a large sample size, and showed that EGR1 and ADAM10 levels were associated well with the different subtypes of sepsis patients.
|
31387910 |
2019 |
|
rs653765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant difference in the genotype and allele frequencies of the rs653765 SNP between patients with sepsis subtype and severe sepsis (P = 0.0014) or severe sepsis/sepsis shock (P = 0.0037) were observed.
|
25888255 |
2015 |
|
rs11684747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls).
|
27607600 |
2016 |
|
rs11689958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls).
|
27607600 |
2016 |
|
rs12692386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No associations were observed between these polymorphisms and sepsis susceptibility, while the rs12692386GA/GG genotypes were overrepresented among the patients with severe sepsis (P=0.002) or septic shock (P=0.0147) compared to those with sepsis subtype, suggesting a susceptible role of rs12692386A>G in the progression of sepsis.
|
27607600 |
2016 |
|
rs12692386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study has provided potentially valuable clinical evidence that the ADAM17 rs12692386 polymorphism is a functional variant that might be used as a relevant risk estimate for the progression of sepsis.
|
27607600 |
2016 |
|
rs1524668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study analyzed the associations of five ADAM17 promoter polymorphisms (rs55790676, rs12692386, rs11684747, rs1524668 and rs11689958) with sepsis (370 sepsis cases and 400 controls).
|
27607600 |
2016 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we analyzed the association of sepsis with three functional RAGE gene polymorphisms (rs1800624, rs1800625 and rs2070600) in a Chinese Han population (372 sepsis cases and 400 healthy controls).
|
27172264 |
2017 |
|
rs1800625
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs1800625 polymorphism is a functional single nucleotide polymorphism and confers host susceptibility to sepsis and MODS in patients with major trauma.
|
25572180 |
2015 |
|
rs1800625
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant differences were observed in the rs1800624 and rs1800625 genotype/allele distributions between the sepsis and controls, but no significant difference was observed in the rs2070600 genotype/allele.
|
27172264 |
2017 |
|
rs1800625
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs1800625 polymorphism is a functional variant, which might be used as a relevant risk estimate for the development of sepsis and multiple organ dysfunction syndrome in patients with major trauma.
|
22827914 |
2012 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, our results also revealed a significant difference in the genotype/allele frequencies of the rs1800624 and rs1800625 polymorphisms between the sepsis and severe sepsis subtypes, the rs1800624 TT or rs1800625 TT genotype carriers exhibited a significant increase in RAGE mRNA, sRAGE, TNF-α and IL-6 expression compared with the rs1800624 AT/AA or rs1800625 CT/CC carriers in sepsis patients.
|
27172264 |
2017 |
|
rs17602729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The common 34C>T loss-of-function variant of AMPD1 (rs17602729) is associated with increased adenosine formation, but effects on immune function and outcome in sepsis patients are unknown.
|
26529652 |
2015 |
|
rs11216153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs11216153 polymorphism of ApoA1 was associated with ALI, the GG genotype and G allele was common in the ALI patients (76.9%, 88.1%, respectively) than both in the control subjects (55.8%, 75.8%, respectively) and in the sepsis alone patients (58.2%, 78.4%, respectively).
|
24885977 |
2014 |
|
rs506027
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that ATG5 expression levels decreased with the severity of sepsis, and rs506027 T > C and rs510432 G > A were associated with sepsis progression and mortality.
|
28839236 |
2017 |
|
rs510432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that ATG5 expression levels decreased with the severity of sepsis, and rs506027 T > C and rs510432 G > A were associated with sepsis progression and mortality.
|
28839236 |
2017 |
|
rs4358188
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both).
|
25000179 |
2014 |
|
rs4358188
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To determine whether the genotype frequencies of the five bi-allelic polymorphisms in the bactericidal/permeability increasing protein (BPI) (Lys216 --> Glu; PstI polymorphism in intron 5; silent mutation G545 --> C) and the lipopolysaccharide binding protein (LBP) (Cys98 --> Gly; Pro436 --> Leu) are associated with the incidence and lethality of sepsis.
|
11373419 |
2001 |
|
rs497116
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis.
|
22615879 |
2012 |
|
rs6586282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to describe the association of this SNP and variants of a splice donor-affecting variable-number tandem repeat (VNTR, NG_008938.1:g.22763_22793[16_22]) 243 bp downstream of rs6586282 with severe human sepsis.
|
26508567 |
2016 |