|
rs1554162524
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1556408009
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Sepsis independently associated with HF, increased NOx, peripheral neutrophils, and fibrinogen levels, decreased prothrombin and the presence of the NOS3 (E298D) and NOS2A (exon 22) SNPs.
|
25239655 |
2014 |
|
rs2066844
|
|
|
0.020 |
GeneticVariation |
BEFREE |
R702W, G908R, and Leu1007fsinsC variants in the NOD2/CARD15 gene were determined as significant risk factors associated with susceptibility to sepsis (p = .025, p = .031, p = .014, respectively).
|
21460759 |
2012 |
|
rs2027432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs2027432 and rs12048215 polymorphisms might be used as relevant risk estimates for the development of sepsis and MOD syndrome in patients with major trauma, in which rs2027432 might be a functional SNP.
|
22112657 |
2011 |
|
rs41279766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H101Q heterozygotes had increased sepsis risk, but further research is required to confirm this finding.
|
23154236 |
2013 |
|
rs842647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs842647 polymorphism might be used as relevant risk estimate for the development of sepsis and MOD syndrome in patients with major trauma.
|
25880845 |
2015 |
|
rs1065489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
rs1061170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs1061170 C/T) and susceptibility to sepsis caused by bacterial infections in Chinese Han populations.
|
31525397 |
2020 |
|
rs231775
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study by our working group revealed that the rs231775 single nucleotide polymorphism (SNP) in the CTLA-4 gene was associated with the survival of patients with sepsis and served as an independent prognostic variable.
|
30634576 |
2019 |
|
rs653765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant difference in the genotype and allele frequencies of the rs653765 SNP between patients with sepsis subtype and severe sepsis (P = 0.0014) or severe sepsis/sepsis shock (P = 0.0037) were observed.
|
25888255 |
2015 |
|
rs2839693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 13 tag single nucleotide polymorphisms, four single nucleotide polymorphisms (rs1429638, rs266087, rs2297630, and rs2839693) were significantly associated with the susceptibility to sepsis, and three (rs3117604, rs1429638, and rs4074) were significantly associated with an increased multiple organ dysfunction score in the derivation cohort.
|
30489503 |
2019 |
|
rs4919510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 9 selected SNPs with potential functional significance, only 1 (miR-608 rs4919510) was found to be strongly associated with a higher risk of developing sepsis and multiple organ dysfunction in all 3 independent study cohorts.
|
24743625 |
2015 |
|
rs773520745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another with mis-sense IL12RB1 mutation (Arg211Pro) was noted as recurrent Salmonella enteritidis D sepsis and pneumatocele.
|
18972195 |
2009 |
|
rs7022797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of limited sample size, conclusive findings could not be drawn in African-descent ARDS subjects; however, significant associations were found for two promoter SNPs (rs7022797 -1899T/G; rs11137480 -1785G/C), across two ED samples supporting the association of alleles -1899G and -1785C with decreased risk for sepsis-associated ARDS.
|
23911438 |
2013 |
|
rs11137480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because of limited sample size, conclusive findings could not be drawn in African-descent ARDS subjects; however, significant associations were found for two promoter SNPs (rs7022797 -1899T/G; rs11137480 -1785G/C), across two ED samples supporting the association of alleles -1899G and -1785C with decreased risk for sepsis-associated ARDS.
|
23911438 |
2013 |
|
rs1800629
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Carriage of the TNF rs1800629 A allele was associated with higher TNF-alpha serum concentrations on the first day after trauma and during follow-up (two-sided p = 5.0 x 10(-5)), with development of sepsis syndrome (odds ratio 7.14, two-sided p = 1.2 x 10(-6); external validation sample [n = 76]: odds ratio 3.3, one-sided p = .03), and with fatal outcome (odds ratio 7.65, two-sided p = 1.9 x 10(-6)).
|
18434886 |
2008 |
|
rs1129055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD86 gene polymorphisms rs1129055 and rs1915087 may increase the risk of sepsis.
|
30343689 |
2018 |
|
rs1915087
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CD86 gene polymorphisms rs1129055 and rs1915087 may increase the risk of sepsis.
|
30343689 |
2018 |
|
rs1800777
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.
|
30425299 |
2018 |
|
rs653765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Clinical data showed that the rs653765 G→A polymorphism was positively correlated with the development of sepsis, as evidenced by a multiple-center case-control association study with a large sample size, and showed that EGR1 and ADAM10 levels were associated well with the different subtypes of sepsis patients.
|
31387910 |
2019 |
|
rs3091244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
rs2808630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CONCLUSIONS Our study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis.
|
29379005 |
2018 |
|
rs11568821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data provide first associative evidence for PD-1 rs11568821 as a prognostic indicator in patients with sepsis.
|
24463978 |
2014 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) -786T→C and 894G→T polymorphisms have been associated with eNOS dysfunction, which might further compromise microcirculatory blood flow during sepsis and increase the risk of organ injury.
|
21336191 |
2011 |