|
rs1492099
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>miR-155</i> rs767649 polymorphism does not seem to be a key determinant of IS risk, whereas the <i>AT1R</i> rs1492099 polymorphism is linked to reduced LAA-stroke risk, and the rs275653 AA genotype is potentially protective against SAO strokes.
|
31721599 |
2020 |
|
rs17669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, miR-122 rs17669 is a significant predictor for the risk of recurrent stroke, independent of traditional risk factors.
|
31811586 |
2020 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the subgroup analyses, polymorphisms of Asp358Ala were significantly associated with the risk of LAA stroke in additive model, dominant model and recessive model (<i>P</i> = 0.009, <i>P</i> = 0.017, <i>P</i> = 0.012, respectively) for male, but not for female.
|
31679401 |
2020 |
|
rs275653
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>miR-155</i> rs767649 polymorphism does not seem to be a key determinant of IS risk, whereas the <i>AT1R</i> rs1492099 polymorphism is linked to reduced LAA-stroke risk, and the rs275653 AA genotype is potentially protective against SAO strokes.
|
31721599 |
2020 |
|
rs852426
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACTB rs852426 was significantly associated with alcohol consumption on stroke risk, and the expression of ACTB mRNA in IS who had a drinking habit was significantly down-regulated.
|
31327802 |
2020 |
|
rs10089084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs10435816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis indicated that rs10435816 (additive model: OR=0.61, 95%CI, 0.41-0.89; recessive model: OR=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: OR=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: OR=0.66, 95%CI, 0.46-0.95; recessive model: OR=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: OR=0.69, 95%CI, 0.48-0.97; recessive model: OR=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.
|
31660817 |
2019 |
|
rs10488682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs10988134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs112896372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In CRT-exposed Europeans, rs112896372 significantly (<i>P</i> < 0.001) improved predictive ability (AUC = 0.717) for determining stroke risk than nongenetic factors alone (AUC = 0.663) at 30 years since diagnosis, with significant improvement among African survivors (<i>P</i> = 0.047).
|
31462438 |
2019 |
|
rs11792633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis indicated that rs10435816 (additive model: OR=0.61, 95%CI, 0.41-0.89; recessive model: OR=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: OR=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: OR=0.66, 95%CI, 0.46-0.95; recessive model: OR=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: OR=0.69, 95%CI, 0.48-0.97; recessive model: OR=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.
|
31660817 |
2019 |
|
rs1353702185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we have previously described that the human Tp53 Arg72Pro single nucleotide polymorphism (SNP) controls susceptibility to ischemia-induced neuronal apoptosis and governs the functional outcome of patients after stroke.
|
29687302 |
2019 |
|
rs1480544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs1799913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs1800532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs2074633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the CC genotype of rs2074633 and rs28688791 (rs2074633, P = 0.019; rs28688791, P = 0.023) showed significant association with unfavorable short-term outcome of LAA stroke.
|
30565168 |
2019 |
|
rs2274924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TRPM6 rs2274924 polymorphism may be associated with susceptibility to epilepsy following stroke, and the C allele may be associated with increased risk of post-stroke epilepsy.
|
30739590 |
2019 |
|
rs3787268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple logistic analysis showed that prestroke antiplatelet therapy, prestroke anticoagulant therapy, rs3918242 CT/TT, and rs3787268 AG/GG were independent predictors for stroke severity.
|
31012282 |
2019 |
|
rs3824259
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs4570625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs4636297
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> The miR-126 gene rs4636297 polymorphism was associated with decreased small vessel stroke risk (GA vs. GG: odds ratio (OR) = 0.62, <i>p</i> = .015; GA + AA vs. GG: OR = 0.637, <i>p</i> = .018; A vs. G: OR = 0.696, <i>p</i> = .033).
|
30895838 |
2019 |
|
rs4762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The M235T and T174M polymorphisms represented an increased risk for stroke in young Mexican individuals.
|
30521887 |
2019 |
|
rs587777940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, treatment with the protease-dead recombinant tPA-S478A holds particular promise as a neurorestorative therapy, as the risk for triggering intracranial hemorrhage is eliminated and tPA-S478A can be delivered intranasally hours after stroke.
|
30996120 |
2019 |
|
rs61921502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study investigated the relationship between the MSRB3 SNP rs61921502, G (minor/risk allele) and MRI measures of brain injury including total brain volume, hippocampal volume, and white matter hyperintensities using linear regression models; the presence of brain infarcts using logistic regression models; and the incidence of stroke, dementia, and AD using Cox proportional hazards models in 2,038 Framingham Heart Study Offspring participants with MRI administered close to examination cycle 7 (1998-2001).
|
30775993 |
2019 |
|
rs623580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |