|
rs7025417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis indicated that rs10435816 (additive model: OR=0.61, 95%CI, 0.41-0.89; recessive model: OR=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: OR=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: OR=0.66, 95%CI, 0.46-0.95; recessive model: OR=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: OR=0.69, 95%CI, 0.48-0.97; recessive model: OR=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.
|
31660817 |
2019 |
|
rs7044343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analysis indicated that rs10435816 (additive model: OR=0.61, 95%CI, 0.41-0.89; recessive model: OR=0.56, 95%CI, 0.40-0.80), rs7025417 (additive model: OR=0.57, 95%CI, 0.39-0.83), rs11792633 (additive model: OR=0.66, 95%CI, 0.46-0.95; recessive model: OR=0.67, 95%CI, 0.49-0.93), and rs7044343 (additive model: OR=0.69, 95%CI, 0.48-0.97; recessive model: OR=0.67, 95%CI, 0.49-0.91) were associated with a decreased risk of large-artery atherosclerosis stroke after adjustment of confounding factors.
|
31660817 |
2019 |
|
rs7124442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for age and sex, logistic regression analysis showed that IS patients harbored with rs7124442 TC genotype had a milder initial stroke (Dominant model: OR = 0.45, 95% CI = 0.25-0.81, P = 0.015), and also showed a better short-term recovery (Dominant model: OR = 0.39, 95% CI =0.24-0.68, P = 0.003).
|
31819463 |
2019 |
|
rs7173743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further stratification according to IS subtypes indicated that carriers with the variant alleles of the rs3825807, rs11634042 and rs7173743 variants of <i>ADAMTS7</i>conferred a lower risk of developing large-artery atherosclerosis stroke subtype.
|
31460868 |
2019 |
|
rs7692387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele benefited from aspirin in two long-term, randomized placebo-controlled trials of aspirin in primary CVD prevention: the Women's Genome Health Study (WGHS, N = 23 294) and a myocardial infarction (MI, N = 550) and stroke (N = 382) case-control set from the Physician's Health Study (PHS, N = 22 071).
|
31228190 |
2019 |
|
rs7857345
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b> The present research on the carotid artery stenosis patient cohort suggests the significant association between the rs4977574, rs7857345 and rs3798220 polymorphisms and carotid artery stenosis as well as between the rs4977574 and rs7857345 polymorphisms and atherogenic stroke.
|
31824394 |
2019 |
|
rs7963803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, this study aimed to investigate the association between the occurrence of <i>TPH1, TPH2, KAT1, KAT2</i> and <i>IDO1</i> polymorphisms and the risk of stroke development.The following 10 polymorphisms of the genes encoding enzymes of the TRYCATs pathway were selected: c.804-7C > A (rs10488682), c.-1668T > A (rs623580), c.803+221C > A (rs1800532), c.-173A > T (rs1799913) - <i>TPH1</i>, c.-1449C > A (rs7963803), and c.-844G > T (rs4570625) - <i>TPH2</i>. c.*456G > A of <i>KAT1</i> (rs10988134), c.975-7T > C of <i>KAT2</i> (rs1480544), c.-1849C > A (rs3824259) and c. -1493G > C (rs10089084) of <i>IDO1</i>.
|
31817010 |
2019 |
|
rs9340799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no evidence of a significant association between ESR1 rs9340799 polymorphism and stroke risk.
|
31533892 |
2019 |
|
rs104895564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One individual with stroke was a carrier for the p.Arg284Ter variant in the NLRP12 gene, which is associated with familial cold autoinflammatory syndrome 2.
|
30183354 |
2018 |
|
rs10848683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And rs10848683 was also found to associate with LAA stroke under recessive model (p = 0.027, OR = 0.618, 95% CI: 0.403-0.947) after adjustment for gender and age.
|
29683785 |
2018 |
|
rs1132896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPStats, Haploview was used to analyze genetic data.Two SNPs in the MMP-2 gene were significantly associated with stroke risk.For rs1132896 (C versus G allele), the C allele was significantly reduced stroke risk (OR = 0.56, 95% confidence intervals [95% CI] = 0.39-0.81, P = .002).
|
30278505 |
2018 |
|
rs1317118140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another patient with stroke and a pulmonary embolism was heterozygous for the p.Pro106Leu variant of the MPL gene, which has been associated with thrombocytosis.
|
30183354 |
2018 |
|
rs147270785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the <i>MASP1</i> and <i>MASP2</i> genes, respectively, are strongly associated with ischaemic stroke, and the minor rs3203210*C and rs147270785*A alleles of these polymorphisms may be considered as protective factors for ischameic stroke, at least in the Armenian population.
|
28720568 |
2018 |
|
rs1558902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association between BMI and the risk of stroke is observed; however, the sensitivity analyses suggest that the association is attributed to the potential pleiotropic effects of rs2867125 and rs1558902.
|
28964830 |
2018 |
|
rs17222919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that ALOX5AP-rs17222919-1316T/G may be a protective factor aginst stroke.
|
30313062 |
2018 |
|
rs17568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, no susceptibility between CHD and stroke and rs17</span>568 polymorphism was uncovered (GG vs. AA: OR=1.04, 95% CI=0.74-1.46; GA vs. AA: OR=1.07, 95% CI=0.62-1.83; GG+GA vs. AA: OR=1.13, 95% CI=0.82-1.56; GG vs. GA+AA: OR=1.01, 95% CI=0.74-1.39).
|
29424751 |
2018 |
|
rs2072446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results obtained indicate that the minor allele of rs6330 (P <sub>corr</sub> = 2.4E-10) and rs2072446 (P <sub>corr</sub> = 0.02) are significantly overrepresented in stroke group, while the minor allele of rs734194 (P <sub>corr</sub> = 8.5E-10) was underrepresented in diseased subjects.
|
29499660 |
2018 |
|
rs215976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that significant difference existed between haplotypes (rs229961-rs215976-rs216008-rs10848683) and LAA stroke (C-T-C-C, p = 0.017, OR = 2.265, 95%CI: 1.136-4.518; G-C-C-C, p = 0.046, OR = 1.891, 95% CI: 1.003-3.565; C-T-C-T, p = 0.001, OR = 0.256, 95%CI: 0.101-0.645).
|
29683785 |
2018 |
|
rs216008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that significant difference existed between haplotypes (rs229961-rs215976-rs216008-rs10848683) and LAA stroke (C-T-C-C, p = 0.017, OR = 2.265, 95%CI: 1.136-4.518; G-C-C-C, p = 0.046, OR = 1.891, 95% CI: 1.003-3.565; C-T-C-T, p = 0.001, OR = 0.256, 95%CI: 0.101-0.645).
|
29683785 |
2018 |
|
rs2271347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients harboring the PARP-1 rs2271347 GA/AA genotype had a worse initial stroke (additive model: OR: 1.85; 95% CI: 1.10-3.11; p = 0.021).
|
30260276 |
2018 |
|
rs229961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that significant difference existed between haplotypes (rs229961-rs215976-rs216008-rs10848683) and LAA stroke (C-T-C-C, p = 0.017, OR = 2.265, 95%CI: 1.136-4.518; G-C-C-C, p = 0.046, OR = 1.891, 95% CI: 1.003-3.565; C-T-C-T, p = 0.001, OR = 0.256, 95%CI: 0.101-0.645).
|
29683785 |
2018 |
|
rs2339840
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the first time, the common variant rs2339840</span> was reported to be a protective factor against stroke in CHD patients with PCI.
|
29742731 |
2018 |
|
rs243832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We did not found any strong linkage between the six SNPs (rs1132896, rs1053605, rs243849, rs243847, rs243832, rs7201)The results presented strongly indicate that MMP-2 genetic variants are an important mediator of stroke risk.
|
30278505 |
2018 |
|
rs285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that risk of stroke was decreased in rs320 and rs285 polymorphisms in the LPL gene.
|
30140409 |
2018 |
|
rs2867125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association between BMI and the risk of stroke is observed; however, the sensitivity analyses suggest that the association is attributed to the potential pleiotropic effects of rs2867125 and rs1558902.
|
28964830 |
2018 |