|
rs12649507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BHLHB2 rs2137947 for major depressive disorder and CLOCK rs12649507 for bipolar disorder were the most significant third loci in the three-locus combination model.
|
31323592 |
2019 |
|
rs135745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TIMELESS rs4630333 and CSNK1E rs135745 were significantly associated with both major depressive disorder and bipolar disorder.
|
31323592 |
2019 |
|
rs2137947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BHLHB2 rs2137947 for major depressive disorder and CLOCK rs12649507 for bipolar disorder were the most significant third loci in the three-locus combination model.
|
31323592 |
2019 |
|
rs4630333
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TIMELESS rs4630333 and CSNK1E rs135745 were significantly associated with both major depressive disorder and bipolar disorder.
|
31323592 |
2019 |
|
rs7997012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
|
rs10514299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.
|
30006604 |
2018 |
|
rs12476147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12476147 (P=0.0078) was associated significantly with schizophrenia, but no SNPs showed statistically significant associations with major depressive disorder after Bonferroni correction.
|
29112096 |
2018 |
|
rs1344706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we also found that haplotype block 2, which included rs12476147 and rs1344706, was associated significantly with schizophrenia and major depressive disorder.
|
29112096 |
2018 |
|
rs68081839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An intronic variant at the GRIA4 locus, rs68081839, was significantly associated with ND-MD comorbidity (β = 0.69 [95% CI, 0.43-0.89], P = 1.53 × 10<sup>-8</sup>).
|
30287806 |
2018 |
|
rs10748842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Principally, the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk genotype and are increased in mood disorders further implicates a molecular mechanism of psychiatric risk at the NRG3 locus and identifies a potential developmental role for NRG3 in bipolar disorder and major depression.
|
27771971 |
2017 |
|
rs11904814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |
|
rs139438618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under the linear regression model, rs139438618 at the semaphorin 3A (SEMA3A [OMIM 603961]) locus was significantly associated with AD and MD comorbidity in African American participants in the Yale-Penn 1 sample (β = 0.89; 95% CI, 0.57-1.20; P = 2.76 × 10-8).
|
29071344 |
2017 |
|
rs1432441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1549854 and rs1432441 polymorphisms of the MAP2K1 gene may be associated with major depressive disorder, especially in females.
|
28688265 |
2017 |
|
rs1488864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, novel associations of PRKCDBP rs1488864 with depressive disorders (q=0.02) and with major depressive disorder in specific (q=0.007) were found.
|
27721187 |
2017 |
|
rs1549854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1549854 and rs1432441 polymorphisms of the MAP2K1 gene may be associated with major depressive disorder, especially in females.
|
28688265 |
2017 |
|
rs1799752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When individuals with major depression on at least one occasion were analyzed, a significant association (OR: 2.14 [95% CI: 1.13-4.20], z = 2.28, p = 0.02), remaining after exclusion of dementia, with rs1799752 in ACE was found.
|
27639288 |
2017 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polymorphism of vitamin D in patients with established diagnosis of major depressive disorder in order to investigate the impact of vitamin D levels and genetic polymorphisms on etiology and/or severity of the disease.
|
28636576 |
2017 |
|
rs2253206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |
|
rs2551941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |
|
rs4290270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia.
|
28084537 |
2017 |
|
rs6195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After conservative correction of Type-I-error to obtain reliable p values, one SNP in the NR3C1 gene, namely rs6195, showed a significant association with the presence of a major depression (p = 0.048) in females.
|
27549215 |
2017 |
|
rs6740584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events.
|
28225778 |
2017 |
|
rs6857715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.
|
27584037 |
2017 |
|
rs7294919
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TESC gene-regulating genetic variant (rs7294919) affects hippocampal subfield volumes and parahippocampal cingulum white matter integrity in major depressive disorder.
|
28575645 |
2017 |
|
rs1137070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a synonymous SNP rs1137070 showing significant associations with major depressive disorder (p = 0.00067, OR = 1.263 for T allele) and schizophrenia (p = 0.0039, OR = 1.225 for T allele) as well as a broad spectrum of psychiatric phenotype (p = 0.000066, OR = 1.218 for T allele) in both males and females.
|
26227907 |
2016 |