|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
rs1006737
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
|
rs10233018
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
|
27089181 |
2016 |
|
rs10405744
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.
|
25944848 |
2015 |
|
rs10447760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that the rare variant rs10447760 in FoxP2 may play an important role in schizophrenia and major depression in the Chinese Han population.
|
22404659 |
2013 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.
|
22306099 |
2012 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results suggested that C3435T polymorphism in the ABCB1 gene may be an indicator of the susceptibility to major depression, without a likely treatment response to citalopram in a Turkish population.
|
24911075 |
2014 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results indicated that MDR1 variants G2677T and C3435T are not associated with therapeutic response to paroxetine in patients with major depressive disorder.
|
18550244 |
2008 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results show that SERTPR-LL genotype might predispose significantly better paroxetine treatment response compared to SS genotype in MDD patients and that variants G2677T and C3435T are not associated with therapeutic response to paroxetine in patients with major depressive disorder.
|
17914325 |
2007 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
|
rs10485715
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide environment interaction between depressive state and stressful life events.
|
26845276 |
2016 |
|
rs1049353
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression.
|
18579347 |
2008 |
|
rs1049353
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We assessed the CB1 receptor gene (CNR1) single nucleotide polymorphism (SNP) rs1049353 (1359 G/A) and the fatty acid amide hydrolase (FAAH) gene rs324420 SNP (cDNA 385C to A) for their associations with MD and/or BD in 83 Caucasian patients with recurrent MD, 134 Caucasian individuals with BD, and 117 Caucasian healthy subjects.
|
20080186 |
2010 |
|
rs1049353
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs1049353 polymorphism also buffered the effects of childhood physical abuse on major depressive disorder; however, this influence was largely attributable to anhedonic depression.
|
22393204 |
2012 |
|
rs1049353
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Haplotype frequency distributions between MD sample and controls showed a significant difference for Block 1 (rs806368-rs1049353-rs806371) (p = 0.008).
|
23407780 |
2013 |
|
rs10494251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we found that rs672607 was significant in major depressive disorder (P = .001) and bipolar disorder (P = .03), and rs10494251 (P = .04), rs1541187 (P = .04), rs688325 (P = .02), and rs946903 (P = .006) were significant in major depressive disorder.
|
21383261 |
2011 |
|
rs10514299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The major depressive disorder GWAS-supported variant rs10514299 in TMEM161B-MEF2C predicts putamen activation during reward processing in alcohol dependence.
|
30006604 |
2018 |
|
rs10748842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Principally, the finding that NRG3 classes II and III are brain-specific isoforms predicted by rs10748842 risk genotype and are increased in mood disorders further implicates a molecular mechanism of psychiatric risk at the NRG3 locus and identifies a potential developmental role for NRG3 in bipolar disorder and major depression.
|
27771971 |
2017 |
|
rs10809520
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
|
27089181 |
2016 |
|
rs10884216
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
|
27089181 |
2016 |