|
rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One hundred and five patients with major depression and 74 unrelated matched controls were analyzed for a silent 1287G/A polymorphism (NET-8) in exon 9 of the NET gene.
|
10512149 |
1999 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000.
|
10686553 |
2000 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design.
|
11803534 |
2001 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls.
|
11311507 |
2001 |
|
rs6314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls.
|
11311507 |
2001 |
|
rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case control association study we investigated the newly identified T-182C polymorphism and an already known G1287A polymorphism in exon 9 of the NET gene in a sample of 193 patients with major depression and 136 healthy, non-related controls.
|
11927173 |
2002 |
|
rs1045642
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
|
rs1415088003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the angiotensin I converting enzyme (ACE) ID and the G-protein beta3-subunit (Gbeta3) C825T polymorphism in 201 patients with unipolar major depression and 161 ethnically and age-matched controls.
|
12476328 |
2002 |
|
rs6296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.
|
12496953 |
2003 |
|
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study.
|
15583702 |
2005 |
|
rs1352618632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR.
|
15866548 |
2005 |
|
rs140504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR.
|
15866548 |
2005 |
|
rs1805054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between the 5-HT6 receptor C267T polymorphism and response to antidepressant treatment in major depressive disorder.
|
15823158 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |
|
rs120074175
|
|
|
0.030 |
GeneticVariation |
BEFREE |
It was recently reported that a rare functional variant, R441H, in the human tryptophan hydroxylase-2 gene (hTPH2) could represent an important risk factor for unipolar major depression (UP) since it was originally found in 10% of UP patients (vs. 1.4% in control subjects).
|
16581035 |
2006 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association with unipolar major depression</span> of one SNP (rs4291) located in the promoter region of the ACE gene was confirmed in our replication sample.
|
16924268 |
2006 |
|
rs821616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
|
16959794 |
2006 |
|
rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population.
|
17917281 |
2007 |
|
rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed the NET promoter T-182C polymorphism and another silent polymorphism G1287A in exon 9 of the NET gene with a polymerase chain reaction (PCR)-based method in 216 patients with major depression and 210 unrelated, age-and sex-matched healthy control subjects.
|
17353941 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects.
|
17404118 |
2007 |