Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1220000453
rs1220000453
0.010 GeneticVariation BEFREE We found no association between CNTF null-mutation and BDNF C270T polymorphism to any depressive symptoms after exclusion of demented subjects. 16797081

2006

dbSNP: rs2606345
rs2606345
0.010 GeneticVariation BEFREE Among Caucasian women, those with the CYP1A1 rs2606345 CC and AC genotypes had approximately 2-fold greater odds of having depressive symptoms than did those with the AA genotype (95% confidence intervals [CIs], 1.33 to 4.66 and 1.25 to 3.14, respectively). 16949393

2006

dbSNP: rs936306
rs936306
0.010 GeneticVariation BEFREE In Japanese women, the odds of depressive symptoms were nearly 5-fold higher among those with CYP 19 rs936306 TT genotype (95% CI, 1.10 to 22.17) than in women with the CC genotype and 9.6-fold higher (95% CI, 2.01 to 45.81) than in women with the CT genotype. 16949393

2006

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism was examined in DNA samples from the mothers and daughters, and measures of depressive symptoms and rumination were also obtained. 17959306

2007

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism was examined in DNA samples from the mothers and daughters, and measures of depressive symptoms and rumination were also obtained. 17959306

2007

dbSNP: rs6313
rs6313
0.040 GeneticVariation BEFREE Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism. 17525976

2007

dbSNP: rs6313
rs6313
0.040 GeneticVariation BEFREE Individuals carrying the T/T or T/C genotype of the T102C polymorphism of the HTR2A gene were responsive to the protective aspects of nurturing mothering, so that in the presence of high maternal nurturance, they expressed low levels of depressive symptoms, while this was not true with the carriers of the C/C genotype. 17339524

2007

dbSNP: rs6313
rs6313
0.040 GeneticVariation BEFREE There was a significant gene-environment interaction, such that the urban residency was associated with low depressive symptoms in individuals carrying the T/T or T/C genotype of the T102C polymorphism, but not in those carrying the C/C genotype. 17510953

2007

dbSNP: rs6313
rs6313
0.040 GeneticVariation BEFREE This study suggests a mechanism for the generation of different neuropsychiatric symptoms in AD from a single nucleotide polymorphism with reduced receptor binding in T102C 5-HT2A receptor gene homozygotes correlating with susceptibility to depressive symptoms, whereas the relative preservation of receptor binding in heterozygotes with AD correlating with susceptibility to hallucinations. 17481814

2007

dbSNP: rs1800497
rs1800497
0.010 GeneticVariation BEFREE To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults. 17585060

2007

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication. 17579366

2008

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication. 17579366

2008

dbSNP: rs2230912
rs2230912
0.020 GeneticVariation BEFREE After correcting for multiple testing, only the association of the P2RX7 Gln460Arg (rs2230912) polymorphism with depressive symptoms remained significant. 18801407

2008

dbSNP: rs699
rs699
AGT
0.010 GeneticVariation BEFREE Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study. 18628677

2008

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms. 19215635

2009

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview. 19339052

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview. 19339052

2009

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms. 19215635

2009

dbSNP: rs25531
rs25531
0.040 GeneticVariation BEFREE We found no evidence for an association between variants of 5-HTTLPR and rs25531 alleles, and depressive symptoms in Chinese PD patients. 19429111

2009

dbSNP: rs662
rs662
0.010 GeneticVariation BEFREE The PON1 Q192R polymorphism was not associated with self-reported poor health {meta-analysis: odds ratio (OR) = 1.01 [confidence interval (CI) 0.91-1.13], P = 0.80} or depressive symptoms in either study or in meta-analyses [CES-D: OR = 1.01 (CI 0.87-1.17), P = 0.90]. 19651761

2009

dbSNP: rs776943620
rs776943620
ACE
0.010 GeneticVariation BEFREE The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview. 19339052

2009

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. 20230085

2010

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires. 20230085

2010

dbSNP: rs4680
rs4680
0.060 GeneticVariation BEFREE To examine the impact of the catechol-O-methyltransferase (COMT) val(158)met allele on depressive symptoms in young children exposed to early severe social deprivation as a result of being raised in institutions. 20403637

2010

dbSNP: rs1800795
rs1800795
0.030 GeneticVariation BEFREE Epidemiologic analyses verified the health significance of those molecular interactions by documenting increased 10-year mortality risk associated with late-life depressive symptoms that occurred solely for homozygous carriers of the GATA1-sensitive G allele of rs1800795. 20176930

2010