|
rs1080963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Depressive symptoms, but not rs1080963, were also significantly associated with higher fasting insulin, insulin area under the curve and insulin resistance (Homeostasis Model Assessment, Homeostasis Model Assessment-2); rs1080963, but not depressive symptoms, was significantly associated with higher fasting glucose and lower Corrected Insulin Response.
|
30089436 |
2018 |
|
rs112025902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings provide evidence that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be correlated with the risk of depression and depressive symptoms in the Chinese population.
|
27677222 |
2016 |
|
rs11265263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Less common recessive genotypes of two single nucleotide polymorphisms in the CRP gene (rs1800947 and rs11265263) were associated with significantly higher mortality risk (p < 0.006), higher CRP levels (p = 0.029, p = 0.006) and increased depressive symptoms in the PHQ-9 (p = 0.005, p = 0.003).
|
29627531 |
2018 |
|
rs138191010
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant located on chromosome 7 was found to be associated with depressive symptoms at age 13 in ALSPAC (rs138191010: β = 0.142, p = 2.51 × 10<sup>-8</sup>), although this was not replicated.
|
28859627 |
2017 |
|
rs1475157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) GG homozygotes (rs1475157-NRN1) showed higher scores on BSI depressive dimension and on total scores compared to A carriers (corrected p-values: 0.0004 and 0.0003, respectively). ii) a linear trend was detected between GG genotype of rs1475157 and a worse cognitive performance in WCST total correct responses (uncorrected p-value: 0.029). iii) Interaction between rs1475157-NRN1 and Val66Met-BDNF was found to modulate depressive symptoms (p=0.001, significant after correction).
|
28107668 |
2017 |
|
rs7582472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent.
|
22628180 |
2012 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that C3435T polymorphisms in the ABCB1 gene are strongly associated with a predisposition to depression development, the severity of depressive symptoms and the effectiveness of therapy with using different groups of antidepressant agents.
|
26664259 |
2015 |
|
rs1202184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety.
|
20859246 |
2011 |
|
rs1922242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety.
|
20859246 |
2011 |
|
rs11046205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also a significant association between a different ABCC9 gene variant (rs11046205) and depressive symptoms.
|
23780892 |
2013 |
|
rs776943620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The low activity variants of the 5-HTT-linked polymorphic region in the serotonin transporter gene and the Met-allele of a single nucleotide polymorphism (Val66Met) in the gene encoding brain derived neurotrophic factor were independently associated with the presence of stressful life events prior to onset of depression, also when corrected for the effect of age, gender, marital status, personality disorder, neuroticism, and severity of depressive symptoms at the time of interview.
|
19339052 |
2009 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study.
|
18628677 |
2008 |
|
rs1800497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults.
|
17585060 |
2007 |
|
rs165599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs165599 SNP, which has previously been associated with response of depressive symptoms to treatment in patients with MDD, did not impact baseline pain in either gender.
|
20627703 |
2010 |
|
rs749437638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for Bonferroni multiple tests, we found associations between the MAOA c.1460C>T (SNP 1137070), COMT c.472G>A (SNP 4680), MTHFR c.677C>T (SNP 1801133) and ESR1 454(-351) A>G (SNP 9340799) polymorphisms to mild and moderate depressive symptoms in menopausal women.
|
26620113 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was a significant interaction between C-reactive protein (CRP) and the BDNF Val66met polymorphism in predicting cognitive depressive symptoms (p=.004), such that higher CRP was related to more cognitive depressive symptoms among Met allele carriers, but not among Val/Val homozygotes.
|
26967918 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
|
25347540 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Eighty-two healthy adolescent girls were genotyped for the BDNF val66met polymorphism, and their depressive symptoms and physical activity were assessed using questionnaires.
|
20230085 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
|
31197095 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the BDNF Val66Met polymorphism is a significant factor influencing the severity of anxiety/depression symptoms in schizophrenic patients.
|
23532065 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed to moderate the effect of CSA on adult depressive symptoms.
|
19215635 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study has provided the first examination of whether working memory capacity, the BDNF Val66Met polymorphism, and their interaction predict changes in symptoms of depression during the transition to university.
|
24920443 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism was independently associated with prevalent PSD, but not with persistent and incident PSD nor with depressive symptoms severity.
|
23399480 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29).
|
27742526 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results indicated the BDNF Val66Met polymorphism significantly moderated the influence of maternal warmth-reasoning, but not harshness-hostility, on youth depressive symptoms.
|
26510938 |
2016 |