|
rs10055255
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (β = -10.8, 95% confidence interval [95% CI], -17.7 to -3.9; P = .002) and depressive symptoms (β = -3.7, 95% CI, -6.7 to -0.7; P = .02).
|
24075295 |
2014 |
|
rs1008805
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The estimate was derived based on the Wald estimator, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cognitive function and depressive symptoms in GBCS and the association of log 17β-estradiol with genetic determinants in the sample of young women in Hong Kong (n=236).
|
27036929 |
2016 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that C3435T polymorphisms in the ABCB1 gene are strongly associated with a predisposition to depression development, the severity of depressive symptoms and the effectiveness of therapy with using different groups of antidepressant agents.
|
26664259 |
2015 |
|
rs10473984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One single-nucleotide polymorphism (SNP) (rs10473984) within the CRHBP locus showed a significant association with both remission (P = 6.0 x 10(-6); corrected, P = .0026) and reduction in depressive symptoms (P = 7.0 x 10(-7); corrected, P = .00031) in response to citalopram.
|
20368512 |
2010 |
|
rs1080963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Depressive symptoms, but not rs1080963, were also significantly associated with higher fasting insulin, insulin area under the curve and insulin resistance (Homeostasis Model Assessment, Homeostasis Model Assessment-2); rs1080963, but not depressive symptoms, was significantly associated with higher fasting glucose and lower Corrected Insulin Response.
|
30089436 |
2018 |
|
rs10830963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested whether a common variant rs10830963 in the gene encoding Melatonin Receptor 1B influences the known association between depressive symptoms and glycaemic traits in a population-based sample from Western Finland.
|
30089436 |
2018 |
|
rs10914456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, <i>Orx<sub>1</sub></i> rs10914456 variants may affect depressive symptom severity.
|
30596528 |
2019 |
|
rs10997870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode.
|
27424200 |
2016 |
|
rs110402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5-HTTLPR.
|
25422958 |
2014 |
|
rs11046205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also a significant association between a different ABCC9 gene variant (rs11046205) and depressive symptoms.
|
23780892 |
2013 |
|
rs112025902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings provide evidence that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be correlated with the risk of depression and depressive symptoms in the Chinese population.
|
27677222 |
2016 |
|
rs11265263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Less common recessive genotypes of two single nucleotide polymorphisms in the CRP gene (rs1800947 and rs11265263) were associated with significantly higher mortality risk (p < 0.006), higher CRP levels (p = 0.029, p = 0.006) and increased depressive symptoms in the PHQ-9 (p = 0.005, p = 0.003).
|
29627531 |
2018 |
|
rs1143634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong statistical evidence was provided for interactions between: 1) IL-1β (rs1143634) and fear of pain for predicting loss of shoulder flexion and abduction, 2) IL-1β (rs1143634) and anxiety for predicting loss of flexion, and 3) IL-1β (rs1143634) and depressive symptoms for predicting loss of internal rotation.
|
30425562 |
2018 |
|
rs1143643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs16944 minor (A) allele specifically interacted with childhood adversity increasing depressive and anxiety symptoms, while rs1143643's minor (A) allele showed protective effect against depressive symptoms after recent life stress.
|
26891860 |
2016 |
|
rs115482041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite being twice as rare (MAF<0.5%), c.1114C>T showed similar effect and significant association with depressive symptoms in samples from the independent population-based Rotterdam study (N=1604, β<sub>T-allele</sub>=3.60, P-value=3 × 10<sup>-2</sup>).
|
28322274 |
2018 |
|
rs11932595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exploratory associations among the circadian locomotor output cycles kaput gene, CLOCK, single nucleotide polymorphism (SNP), rs11932595, as well as sleep assessments and depressive symptoms also are presented.
|
24332565 |
2014 |
|
rs1200746244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for Bonferroni multiple tests, we found associations between the MAOA c.1460C>T (SNP 1137070), COMT c.472G>A (SNP 4680), MTHFR c.677C>T (SNP 1801133) and ESR1 454(-351) A>G (SNP 9340799) polymorphisms to mild and moderate depressive symptoms in menopausal women.
|
26620113 |
2016 |
|
rs1202184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety.
|
20859246 |
2011 |
|
rs1207568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering the pre-post differences of HRSD-21 scores as a continue variable, we confirmed a significant improvement of depressive symptoms after treatment in patients carrying at least one minor allele at rs1207568 and a worse response in patients homozygous for the minor allele at rs9536314.
|
26843110 |
2017 |
|
rs12137927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found associations meeting multiple testing criteria for significance between the PER3 intronic SNP rs12137927 and decreased odds of reporting "some depressive symptoms" in the SOF sample (odds ratio [OR]: 0.61, 95% confidence interval [CI]: 0.48-0.78, df=1, Wald χ2=-4.04, p=0.000054) and the meta-analysis (OR: 0.61, CI: 0.48-0.78, z=-4.04, p=0.000054) and between the PER3 intronic SNPs rs228644 (OR: 0.74, CI: 0.63-0.86, z=3.82, p=0.00013) and rs228682 (OR: 0.74, CI: 0.86-0.63, z=3.81, p=0.00014) and decreased odds of reporting "some depressive symptoms" in the meta-analysis compared to endorsing none-few depressive symptoms.
|
25892098 |
2015 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for Bonferroni multiple tests, we found associations between the MAOA c.1460C>T (SNP 1137070), COMT c.472G>A (SNP 4680), MTHFR c.677C>T (SNP 1801133) and ESR1 454(-351) A>G (SNP 9340799) polymorphisms to mild and moderate depressive symptoms in menopausal women.
|
26620113 |
2016 |
|
rs1220000453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no association between CNTF null-mutation and BDNF C270T polymorphism to any depressive symptoms after exclusion of demented subjects.
|
16797081 |
2006 |
|
rs12720208
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A statistically significant association of the functional polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found.
|
30241547 |
2018 |
|
rs1290141855
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for Bonferroni multiple tests, we found associations between the MAOA c.1460C>T (SNP 1137070), COMT c.472G>A (SNP 4680), MTHFR c.677C>T (SNP 1801133) and ESR1 454(-351) A>G (SNP 9340799) polymorphisms to mild and moderate depressive symptoms in menopausal women.
|
26620113 |
2016 |
|
rs1360780
|
|
|
0.030 |
GeneticVariation |
BEFREE |
While we observed main effects of sex, age, body mass index, smoking, and depression symptoms on FKBP5 methylation levels, only the functional FKBP5 SNP (rs1360780) moderated the dynamic changes following DEX.
|
31122292 |
2019 |