|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No statistically significant results were found in meta-analysis but one study reported that the rs4680 Val allele was associated with AD-related psychosis.
|
22483294 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results suggest the effects of the BDNF Val66Met allele may be different in patients with psychosis than in healthy adults.
|
22192502 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with schizophreniform psychosis and 53 with affective psychoses) and 191 neighboring healthy controls.
|
23429848 |
2012 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with schizophreniform psychosis and 53 with affective psychoses) and 191 neighboring healthy controls.
|
23429848 |
2012 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results suggest the effects of the BDNF Val66Met allele may be different in patients with psychosis than in healthy adults.
|
22192502 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.
|
21073668 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.
|
21231925 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.
|
21947654 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results had adequate statistical power to suggest that BDNF Val66Met was not related to susceptibility to AD or the onset of AD, but that presence of one or two Met alleles of BDNF Val66Met polymorphism might present a risk factor for psychosis in AD.
|
21044653 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in nuclear families with at least one subject affected by major psychosis with suicidal behaviour, and compared allele-specific mRNA levels in post-mortem brain samples from suicide and non-suicide victims.
|
20726824 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results had adequate statistical power to suggest that BDNF Val66Met was not related to susceptibility to AD or the onset of AD, but that presence of one or two Met alleles of BDNF Val66Met polymorphism might present a risk factor for psychosis in AD.
|
21044653 |
2011 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a family-based association study and ETDT analyses of the Val66Met polymorphism in nuclear families with at least one subject affected by major psychosis with suicidal behaviour, and compared allele-specific mRNA levels in post-mortem brain samples from suicide and non-suicide victims.
|
20726824 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis.
|
20493536 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the BDNF Val66Met polymorphism may contribute to methamphetamine dependence and psychosis in the Chinese population but not in other Malaysian ethnicities.
|
20736000 |
2010 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the BDNF Val66Met polymorphism may contribute to methamphetamine dependence and psychosis in the Chinese population but not in other Malaysian ethnicities.
|
20736000 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were analyzed in a sample of 84 adolescent Caucasian patients with first-episode psychosis (ages 11-17) and 85 healthy Caucasian controls (ages 10-17).
|
18351593 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
|
17525974 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the phenotypic expression of first episode psychosis at onset.
|
18092319 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis.
|
18407467 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P.
|
16837108 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stress on the psychosis outcome than those with the Met/Met genotype (test for interaction: chi2 = 5.02, df = 1, p = 0.025).
|
17640440 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
|
16476412 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics.
|
16969277 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.
|
16936704 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study.
|
16389585 |
2006 |