|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset.
|
21784354 |
2011 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In two independent clinical cohorts, longer lengths of rs10524523 are associated with a higher risk for LOAD.
|
20029386 |
2010 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD.
|
25500937 |
2014 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that in the carriers of TOMM40-APOE haplotypes comprising E4 allele, the TOMM40 rs10524523 allele does not play substantial role in establishing LOAD risk.
|
22008263 |
2012 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine whether a highly polymorphic, intronic poly-T within this region (rs10524523; hereafter, 523) affects expression of the APOE and TOMM40 genes.
|
24439168 |
2014 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease.
|
28768149 |
2017 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant.
|
25862420 |
2015 |
|
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found a significant association between rs10524523 and risk of LOAD in APOE 33 homozygotes but in the opposite direction as the previously reported association (the very long allele was underrepresented in cases vs controls in this study (P = .004]).
|
21825236 |
2011 |
|
rs2075650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings suggest that rs2075650 of TOMM40 could be involved in earlier presentation of LOAD in the Colombian population.
|
27023435 |
2017 |
|
rs2075650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both allelic and genotypic associations of three SNPs (rs157580, rs2075650, and rs11556505) with LOAD risk were observed in the total sample as well as in the non- APOE ε4 carriers.
|
23288655 |
2013 |
|
rs11556505
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both allelic and genotypic associations of three SNPs (rs157580, rs2075650, and rs11556505) with LOAD risk were observed in the total sample as well as in the non- APOE ε4 carriers.
|
23288655 |
2013 |
|
rs139709573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 433 LOAD cases and 3903 controls from the Icelandic AGES sub-study, P155L was associated with increased risk and earlier onset of LOAD [odds ratio (95% CI) = 7.5 (3.5-15.9), p = 6.6x10-9].
|
27764101 |
2016 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data further support a role for innate immunity in neurodegeneration and give the first evidence that the TLR4 Asp299Gly variant may be protective toward the development of LOAD.
|
16157451 |
2006 |
|
rs1937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, rare variants (mutations) in the TFAM gene were not found in LOAD-patients, but the S12T polymorphism was a moderate risk factor for LOAD in our population.
|
18430995 |
2008 |
|
rs1937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further, two synergistic interactions between subhaplogroup H5 and APOE4 status (p = 0.009) and between TFAM rs1937 and APOE4 status (p < 0.001) were detected, influencing LOAD risk.
|
21799244 |
2011 |
|
rs5030882
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
|
rs2269657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the end, only SREBF2 polymorphism rs2269657 showed significant dual associations with LOAD pathological biomarkers and gene expression levels.
|
29503034 |
2018 |
|
rs11218304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
rs1784933
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conversely, a SORL1 gene SNP at the rs1784933 locus is associated with LOAD onset, with the A allele being a risk factor.
|
25450149 |
2015 |
|
rs1784933
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that rs1784933 and rs1805192 minor alleles, gene- gene interaction between rs1784933 and rs1805192, gene- environment interaction between rs1784933 and alcohol drinking, and haplotype containing the rs1784933- A and rs689021- C alleles are all associated with increased LOAD risk.
|
28427149 |
2017 |
|
rs2070045
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SORL1 rs2070045 polymorphism was reported to be associated with SorLA expression in the brain and the risk of late-onset Alzheimer's disease (AD).
|
25598427 |
2015 |
|
rs2070045
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association was revealed between the polymorphism of SNP 19 rs2070045 (T/T, T/G</span>, G/G) and the risk of LOAD.
|
24309291 |
2014 |
|
rs689021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We conclude that rs1784933 and rs1805192 minor alleles, gene- gene interaction between rs1784933 and rs1805192, gene- environment interaction between rs1784933 and alcohol drinking, and haplotype containing the rs1784933- A and rs689021- C alleles are all associated with increased LOAD risk.
|
28427149 |
2017 |
|
rs689021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SORL1 gene SNPs at rs689021 and rs3824966 loci show no relationship with LOAD onset in the Chinese Han population of the Hunan Changsha region.
|
25450149 |
2015 |
|
rs11218343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Result of the case-control study showed the association between rs11218343 polymorphism and the risk of LOAD in a Northern Han Chinese population (recessive model: odds ratio (OR) = 0.641, 95 % confidence interval (CI) = 0.464-0.884, P = 0.007; additive model: OR = 0.873, 95 % CI = 0.765-0.996, P = 0.043).
|
26873856 |
2017 |