|
rs4878104
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A second SNP, rs4877365, which is in high linkage disequilibrium with rs4878104 (r2=0.64), was also significantly associated with LOAD (meta P=0.0017 in the initial three sample sets).
|
16847012 |
2006 |
|
rs165932
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between presenilin 1 intronic polymorphism (rs165932) and late onset Alzheimer's disease (LOAD) has been a matter of controversy.
|
16938285 |
2006 |
|
rs498055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10, significant associations between the rs498055 and rs4417206 SNPs and risk of LOAD were observed.
|
17000046 |
2006 |
|
rs4417206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10, significant associations between the rs498055 and rs4417206 SNPs and risk of LOAD were observed.
|
17000046 |
2006 |
|
rs6084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Hence, rs6084 is not consistently associated with LOAD.
|
17175070 |
2008 |
|
rs4548513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A weak association with the Ser596Asn SNP in the multiplex sample, predominantly in families with late-onset Alzheimer's disease (p = 0.02), was observed.
|
17209133 |
2007 |
|
rs242557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We do not detect evidence that the set of SNPs forming the H1c haplotype in general or rs242557 in particular are pathogenic for LOAD.
|
17266761 |
2007 |
|
rs3817622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that there is an association between rs3817622 and the development of LOAD in APOE epsilon4 carriers within the northern Chinese population.
|
17280645 |
2007 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease.
|
17385092 |
2007 |
|
rs4420638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs4420638 on chromosome 19, located 14 kilobase pairs distal to the APOE epsilon variant, significantly distinguished between AD cases and controls (Bonferroni corrected p value = 5.30 x 10(-34), OR = 4.01) and was far more strongly associated with the risk of AD than any other SNP of the 502,627 tested.
|
17474819 |
2007 |
|
rs4646953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk.
|
17496198 |
2007 |
|
rs4646955
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk.
|
17496198 |
2007 |
|
rs498055
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus we conclude that rs498055 is not associated with an increased risk of LOAD.
|
17725684 |
2008 |
|
rs536360
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the minor T allele in rs556349 and for the minor C allele in rs536360 was associated with later age at onset and reduced risk of AD (HR=0.26, 95% CI: 0.08-0.86; and HR=0.40, 95% CI: 0.16-0.98, respectively).
|
17826910 |
2007 |
|
rs556349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the minor T allele in rs556349 and for the minor C allele in rs536360 was associated with later age at onset and reduced risk of AD (HR=0.26, 95% CI: 0.08-0.86; and HR=0.40, 95% CI: 0.16-0.98, respectively).
|
17826910 |
2007 |
|
rs34637584
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Investigation of the leucine-rich repeat kinase 2 (LRRK2) gene in late-onset Alzheimer's disease (AD) patients to screen for the G2019S mutation, which is common in Parkinson's cases.
|
17846883 |
2007 |
|
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk.
|
17999207 |
2007 |
|
rs1881747
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
|
rs2279420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
|
rs2306402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
|
rs5030882
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated nominally significant association with LOAD for 4 SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P = 0.046, OR = 1.29) in 1,160 cases and 1,389 controls.
|
18163421 |
2008 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that the NOS3 gene Glu298Asp polymorphism might be a risk factor for LOAD and dependent on APOE epsilon 4 status in Chinese.
|
18183499 |
2008 |
|
rs1937
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, rare variants (mutations) in the TFAM gene were not found in LOAD-patients, but the S12T polymorphism was a moderate risk factor for LOAD in our population.
|
18430995 |
2008 |
|
rs11190302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the epsilon4 allele (genotypic P = 0.027, allelic P = 0.066).
|
18452187 |
2009 |
|
rs165932
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association of an intronic polymorphism (rs165932) of the presenilin-1 gene with late-onset Alzheimer's disease has been documented.
|
19017784 |
2008 |