|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association studies confirm that the I148M polymorphism is also a strong modifier of NASH and progressive hepatic injury.
|
23394097 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, the rs738409 G allele is associated with severity of NASH and occurrence of fibrosis in patients with NAFLD.
|
22258181 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH.
|
26273621 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) by still undefined mechanisms, possibly involving regulation of adipose tissue function.
|
22898488 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To develop an animal model of PNPLA3-induced fatty liver disease, we generated transgenic mice that overexpress similar amounts of wild-type PNPLA3 (PNPLA3(WT)) or mutant PNPLA3 (PNPLA3(I148M)) either in liver or adipose tissue.
|
23023705 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previously, we identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that is strongly associated with FLD, but the mechanistic basis for the association remains elusive.
|
31019090 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A missense variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known.
|
29555681 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this study, we report the association of the rs738407, rs738409, and rs2896019 variants of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene with nonalcoholic steatohepatitis (NASH) (χ(2)=14.528, p=0.001; χ(2)=18.882, p=0.000; χ(2)=7.449, p=0.024, respectively) in 80 patients with NASH and 303 healthy controls.
|
24831885 |
2014 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PNPLA3 rs738409 polymorphism is associated with fatty liver disease, alcoholic or non-alcoholic (NAFLD) and hepatocellular carcinoma (HCC).
|
26493626 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Several recent genome-wide association studies have reported an association between single-nucleotide polymorphism rs738409 in the (patatin-like phospholipase domain-containing protein 3) PNPLA3 gene and FLD.
|
22546774 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs738409 and rs58542926 variants, but not rs641738, were associated not only with non-alcoholic steatohepatitis (NASH) (odds ratio [OR], 2.00; 95% confidence interval [CI], 1.46-2.73 and OR, 1.91; 95% CI, 1.04-3.51) but also with significant fibrosis (≥ F2) (OR, 1.53; 95% CI, 1.11-2.11 and OR, 1.88; 95% CI, 1.02-3.46) in NAFLD, even after adjustment for metabolic risk factors.
|
29193269 |
2018 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and hepatocellular carcinoma (HCC) risk is less well-defined.
|
24445574 |
2014 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings suggest that the rs738409 polymorphism in PNPLA3 gene confers high cross-ethnicity risk for NAFLD and NASH development.
|
25791171 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 GG genotype increases susceptibility of NASH in severely obese Asians with NAFLD and correlates to histologic severity of NAFLD.
|
25240529 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, the rs738</span>409 G allele was strongly associated with the severity of steatosis (P < 0.0001), the presence of NASH (P < 0.0001), hepatocellular ballooning (P < 0.0001), lobular inflammation (P < 0.0001), and the presence of fibrosis (P = 0.01) independently of confounders.
|
20648474 |
2010 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In patients without, but not in those with NASH, significant fibrosis was associated with steatosis grade and the PNPLA3 I148M variant.
|
30708111 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The risk of either NASH or F ≥ 2 fibrosis progressively increased with increasing PIIINP levels (P < .0001), independent of age, gender, adiposity measures, insulin resistance, NAS score and the patatin-like phospholipase domain-containing protein-3 rs738409 polymorphism.
|
31436362 |
2019 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PNPLA3 polymorphism rs738409 was associated with NASH and the severity of necroinflammatory changes independently of metabolic factors.
|
23512881 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis.
|
22560221 |
2012 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
They had lower serum lipid levels than noncarriers (P < 0.05), had more-severe steatosis, necroinflammation, ballooning, and fibrosis (P < 0.05), and were more likely to have NASH (odds ratio [OR]: 1.84; 95% confidence interval [CI]: 1.23-2.79) and advanced fibrosis (OR, 2.08; 95% CI: 1.20-3.55), after adjustment for age, sex, body mass index, fasting hyperglycemia, and the I148M PNPLA3 risk variant.
|
25251399 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this cohort of patients with medically complicated obesity, PNPLA3 rs738409 G allelic expression is associated with hepatic (NASH) and nonhepatic complications of obesity, such as insulin resistance.
|
23418085 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The adiponutrin/PNPLA3 (patatin-like phospholipase domain-containing protein 3) variant I148M has recently emerged as an important marker of human fatty liver disease.
|
21145868 |
2011 |