|
rs1007863
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs1010022
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs1010023
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs10499563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL6 rs10499563 C allele was independently associated with the presence of definitive NASH, and increased ballooning and Mallory bodies.
|
27730688 |
2016 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs11090617
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To examine whether the C677T and A1298C polymorphisms of the MTHFR gene were associated with NASH, we analysed the allele and genotype distribution of the MTHFR C677T and A1298C polymorphisms in 57 well-diagnosed NASH patients, 324 healthy controls in a case-control study of Turkish subjects of Caucasian origin.
|
17563923 |
2008 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
According to this study, the MTHFR C677T mutation does not seem to be a risk factor for the progression of NAFL to NASH.
|
17356914 |
2007 |
|
rs12447924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs12483959
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs12597002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs1260326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs1260326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs12743824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs1461729
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs1474745
|
|
|
0.700 |
GeneticVariation |
GWASDB |
The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study.
|
23477746 |
2013 |
|
rs1572982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs17107315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One subject with diffuse fatty liver disease and other with liver cirrhosis due to NAFLD had N34S mutation.
|
19502653 |
2009 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Sex (63-67% male) and age at diagnosis of NASH did not differ between those with or without HFE mutations, but men with NASH were significantly more likely than women to have the H63D mutation (15/23 vs. 3/13, p<0.05) Levels of serum ferritin, iron, transferrin saturation levels, and the degree of hepatic iron staining were significantly higher (p<0.05) in subjects with NASH who carried an HFE mutation than in those without.
|
10488699 |
1999 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
One patient with NASH</span> and one normal individual who were homozygous for H63D showed no iron overload.
|
17589946 |
2007 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We have not found a significantly increased prevalence of the mutation H63D in the HFE gene in our patients with NASH.
|
17916170 |
2008 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism genotyping for C282Y (rs1800562) and H63D (rs1799945) HFE mutations was performed in 786 adult subjects in the NASH Clinical Research Network (CRN).
|
22611049 |
2012 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The frequencies of compound C282Y/H63D heterozygotes (n = 1) or H63D heterozygotes (n = 10) were not increased in NASH.
|
12085358 |
2002 |
|
rs1800206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither NASH nor genotype 1 HCV-related liver steatosis seems to be associated with the PPARalpha L162V polymorphism.
|
16297361 |
2005 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In assessing the C282Y HFE gene mutation alone, the percentage of heterozygosis for C282Y was not different in subjects with NASH compared with controls.
|
17916170 |
2008 |