|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis showed patients carrying the rs1800624 heterozygote genotype (AT) exhibited 2.36-fold increased risk of NASH (odds ratio (OR) = 2.36; 95% confidence interval (95% CI): 1.35-4.19) after adjusting for confounders.
|
29928018 |
2018 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the presented data indicate that the G-A-T-G haplotype containing minor allele at position -374 A and major allele at position -429T, 1704G, and G82S G could be regarded as a marker for NASH.
|
29928018 |
2018 |
|
rs2228530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs4674344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs903361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>ADORA1</i> rs903361 associated with resolution of NASH (<i>p</i> = 0.0005) and change in the ballooning score among Caucasian and Hispanic patients (<i>p</i> = 0.0005).
|
30065651 |
2018 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients at risk for NASH [odds ratio (OR) = 0.64, 95% confidence interval (CI), 0.47 to 0.87; P = 0.005], and more so in the high-risk subgroup of those with impaired fasting glucose/diabetes (OR = 0.44, 95% CI, 0.26 to 0.74; P = 0.002), the rs3480 A>G variant was independently associated with protection from F2 to F4 fibrosis.
|
28472477 |
2017 |
|
rs8050136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs951599607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs9940128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of FL</span>D among rs9940128 AA carriers was 55.7% (63 of 113 individuals) and that in patients without this genotype was 39.7% (204 of 514 individuals) [P = 0.009; adjusted odds ratio 1.88; 95% confidence interval (CI) 1.17-3.01].
|
28116842 |
2017 |
|
rs10499563
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL6 rs10499563 C allele was independently associated with the presence of definitive NASH, and increased ballooning and Mallory bodies.
|
27730688 |
2016 |
|
rs1572982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs2071303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs72563732
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of adiponectin gene promoter-11377C/G(CG), -11377C/G (GG), GPx-1 gene C594T (CT) and C594T (TT) were 24.50%, 26.00%, 24.00%, and 25.50% in the NAFL group, 34.50%, 37.00%, 35.00%, and 36.00% in the NASH group, 42.00%, 46.00%, 43.50%, and 45.50% in the NAFHC group, and 14.00%, 14.50%, 13.00%, and 14.00% in the control group, respectively.
|
26897098 |
2016 |
|
rs8192678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs12743824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs2072906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four linked SNPs of PNPLA3 (rs738409, rs3747206, rs4823173, and rs2072906) are correlated with susceptibility to NAFLD, NASH, liver fibrosis, and HBV dynamics in CHB patients.
|
26229402 |
2015 |
|
rs4880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The anti-oxidative SOD2 47T>C genetic variant might increase susceptibility to NASH in Chinese.
|
24649902 |
2014 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs2645424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs694539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs694539 variant of NNMT gene is a genetic risk factor for developing NASH.
|
23964925 |
2013 |
|
rs12447924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs12597002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs7643645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, in univariate analysis rs7643645/G was significantly associated with fatty liver disease (P<0.04), with an odds ratio of 1.457 (95% confidence interval: 1.018-2.086).
|
19940802 |
2010 |