|
rs12743824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs72563732
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of adiponectin gene promoter-11377C/G(CG), -11377C/G (GG), GPx-1 gene C594T (CT) and C594T (TT) were 24.50%, 26.00%, 24.00%, and 25.50% in the NAFL group, 34.50%, 37.00%, 35.00%, and 36.00% in the NASH group, 42.00%, 46.00%, 43.50%, and 45.50% in the NAFHC group, and 14.00%, 14.50%, 13.00%, and 14.00% in the control group, respectively.
|
26897098 |
2016 |
|
rs903361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>ADORA1</i> rs903361 associated with resolution of NASH (<i>p</i> = 0.0005) and change in the ballooning score among Caucasian and Hispanic patients (<i>p</i> = 0.0005).
|
30065651 |
2018 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the presented data indicate that the G-A-T-G haplotype containing minor allele at position -374 A and major allele at position -429T, 1704G, and G82S G could be regarded as a marker for NASH.
|
29928018 |
2018 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis showed patients carrying the rs1800624 heterozygote genotype (AT) exhibited 2.36-fold increased risk of NASH (odds ratio (OR) = 2.36; 95% confidence interval (95% CI): 1.35-4.19) after adjusting for confounders.
|
29928018 |
2018 |
|
rs12447924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs12597002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |
|
rs4674344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore subclinical fatty liver disease (FLD) in donors as a possible mechanism leading to FLD in recipients of living donor liver transplantation (LDLT), we extracted thirty donor-recipient pairs' serum DNA and explored the presence of CYP2R1 single nucleotide polymorphism (SNP) rs10741657 and vitamin D receptor (VDR) SNP rs2228530 A/G alleles using real-time polymerase chain reaction.
|
29750155 |
2018 |
|
rs2645424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients at risk for NASH [odds ratio (OR) = 0.64, 95% confidence interval (CI), 0.47 to 0.87; P = 0.005], and more so in the high-risk subgroup of those with impaired fasting glucose/diabetes (OR = 0.44, 95% CI, 0.26 to 0.74; P = 0.002), the rs3480 A>G variant was independently associated with protection from F2 to F4 fibrosis.
|
28472477 |
2017 |
|
rs8050136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs8050136, rs9939609 and rs9940128) were associated with FLD, with rs9940128 showing the strongest association.
|
28116842 |
2017 |
|
rs9940128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of FL</span>D among rs9940128 AA carriers was 55.7% (63 of 113 individuals) and that in patients without this genotype was 39.7% (204 of 514 individuals) [P = 0.009; adjusted odds ratio 1.88; 95% confidence interval (CI) 1.17-3.01].
|
28116842 |
2017 |
|
rs1260326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs1260326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs780094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
|
rs1572982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In assessing the C282Y HFE gene mutation alone, the percentage of heterozygosis for C282Y was not different in subjects with NASH compared with controls.
|
17916170 |
2008 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Cys282Tyr mutation is responsible for most of the mild iron overload found in NASH and thus has a significant association with hepatic damage in these patients.
|
9453491 |
1998 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The frequency of C282Y heterozygosity was increased in Anglo-Celtic patients with NASH compared with ethnic blood donor controls (22% vs. 9.2%; P =.035); there were no C282Y homozygotes in the NASH cohort.
|
12085358 |
2002 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism genotyping for C282Y (rs1800562) and H63D (rs1799945) HFE mutations was performed in 786 adult subjects in the NASH Clinical Research Network (CRN).
|
22611049 |
2012 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The HFE C282Y heterozygous mutation is associated with advanced fibrosis among Caucasians with NASH.
|
17680648 |
2007 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
One subject (2.8%) with NASH was homozygous for the C282Y mutation and six (16.7%) were heterozygous, compared with 0%, and 11.2%, respectively, of controls.
|
10488699 |
1999 |
|
rs1799945
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Sex (63-67% male) and age at diagnosis of NASH did not differ between those with or without HFE mutations, but men with NASH were significantly more likely than women to have the H63D mutation (15/23 vs. 3/13, p<0.05) Levels of serum ferritin, iron, transferrin saturation levels, and the degree of hepatic iron staining were significantly higher (p<0.05) in subjects with NASH who carried an HFE mutation than in those without.
|
10488699 |
1999 |