|
rs903361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>ADORA1</i> rs903361 associated with resolution of NASH (<i>p</i> = 0.0005) and change in the ballooning score among Caucasian and Hispanic patients (<i>p</i> = 0.0005).
|
30065651 |
2018 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Val175Met variant of PEMT could be a candidate molecule that determines the susceptibility to NASH, because it is more frequently observed in NASH patients and non-obese persons with Val175Met variant of PEMT are facilitated to develop NASH.
|
17391797 |
2007 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A missense variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known.
|
29555681 |
2018 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
According to this study, the MTHFR C677T mutation does not seem to be a risk factor for the progression of NAFL to NASH.
|
17356914 |
2007 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Association studies confirm that the I148M polymorphism is also a strong modifier of NASH and progressive hepatic injury.
|
23394097 |
2013 |
|
rs58542926
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Carriers of the TM6SF2 E167K variant are more susceptible to progressive NASH, but are protected against cardiovascular disease.
|
25251399 |
2015 |
|
rs72613567
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conclusion: High risk of fatty liver disease amplifies the ALT-lowering effect of HSD17B13 rs72613567:TA in the Danish general population.
|
31155741 |
2020 |
|
rs694539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, the rs694539 variant of NNMT gene is a genetic risk factor for developing NASH.
|
23964925 |
2013 |
|
rs2071303
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs1572982
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Decreased frequencies of the TTA haplotype (T in rs2071303, T in rs1800708, and A in rs1572982) were observed in the groups of patients with diseases associated with overweight (fatty liver disease, type 2 diabetes mellitus, or metabolic syndrome + arterial hypertension) as compared with the control sample.
|
27317329 |
2016 |
|
rs7946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Decreased liver PC content in individuals with the NASH is independent of PEMT V175M genotype and could be partly linked to decreased GNMT expression.
|
31199045 |
2019 |
|
rs58542926
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Decreased liver production/secretion of VLDL, decreased cholesterol and TGs in VLDL/LDL particles in serum, and increased tyrosine levels identify possible mechanisms by which rs58542926-T exerts its effects on increasing risk of fatty liver disease, decreasing cardiovascular disease, and increasing diabetes risk, respectively.
|
28539357 |
2017 |
|
rs4674344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs2228570
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Donor/recipient CYP27A1 rs4674344 and graft VDR rs2228570 may be related to low serum 25(OH)D and may play a major role in the development of fatty liver disease in recipients after living donor liver transplantation.
|
29935100 |
2018 |
|
rs7643645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, in univariate analysis rs7643645/G was significantly associated with fatty liver disease (P<0.04), with an odds ratio of 1.457 (95% confidence interval: 1.018-2.086).
|
19940802 |
2010 |
|
rs2072906
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four linked SNPs of PNPLA3 (rs738409, rs3747206, rs4823173, and rs2072906) are correlated with susceptibility to NAFLD, NASH, liver fibrosis, and HBV dynamics in CHB patients.
|
26229402 |
2015 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs8192678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an additive effect of the PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype on the presence of NASH (OR 6.83; 95% CI 1.61-29.01; P = 0.009).The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH in severely obese Taiwanese patients.
|
27015186 |
2016 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs1260326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs2645424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs738409
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In addition, there were marked differences in rs738409 genotype distributions between type4 subgroup corresponding to NASH and the other three subgroups (p = 4.8 × 10(-6), OR = 1.96, 95%CI: 1.47-2.62).
|
22719876 |
2012 |
|
rs1800562
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In assessing the C282Y HFE gene mutation alone, the percentage of heterozygosis for C282Y was not different in subjects with NASH compared with controls.
|
17916170 |
2008 |
|
rs2070600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the presented data indicate that the G-A-T-G haplotype containing minor allele at position -374 A and major allele at position -429T, 1704G, and G82S G could be regarded as a marker for NASH.
|
29928018 |
2018 |
|
rs12447924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In females, two SNPs in linkage disequilibrium from the CETP gene were associated with FLD: rs12447924 (OR 2.16, 95%CI 1.42-3.32, P=0.0003) and rs12597002 (OR=2.22, 95%CI 1.46-3.41 P=0.0002).
|
22414273 |
2012 |