Malignant neoplasm of lung
|
0.320 |
Therapeutic
|
disease |
CTD_human |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Malignant neoplasm of lung
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Malignant neoplasm of lung
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients.
|
30514297 |
2018 |
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sox30 deficiency promotes lung metastasis in Sox30<sup>-/-</sup> mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression.
|
29739711 |
2018 |
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma.
|
29855376 |
2018 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
stage, ovarian epithelial cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer.
|
30608899 |
2019 |
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX30 regulated HCC progression through aberrant activation of p53 by directly binding to its promoter.
|
30312695 |
2019 |
Clear-cell metastatic renal cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the univariate Cox regression model, SOX1, SOX2, SOX6, SOX11, SOX12, SOX13, SOX15, SOX17 and SOX30 expression were predictive in the prognosis of clear cell RCC.
|
29541226 |
2018 |
Non-obstructive azoospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The pathology and testicular size of Sox30 null mice highly simulate those of NOA patients.
|
31835093 |
2020 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, clinicopathological analyses showed that low SOX30 expression was positively related to an advanced tumor, node, and metastasis (TNM) stage.
|
29880037 |
2018 |