|
Male infertility
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Deletion of Sox30 in mice uniquely impairs testis development and spermatogenesis with complete absence of spermatozoa in testes leading to male infertility, but does not influence ovary development and female fertility.
|
31835093 |
2020 |
|
Hyperactive behavior
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Here, we performed a comparative genome-wide profiling of DNA methylation and identified SOX30 as the most notably hyper-methylated gene at promoter in testicular tissues from NOA patients.
|
31835093 |
2020 |
|
Non-obstructive azoospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The pathology and testicular size of Sox30 null mice highly simulate those of NOA patients.
|
31835093 |
2020 |
|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
miR-125b can regulate SOX30 by binding to its 3'UTR. miR-125b and SOX30 act as diagnostic and therapeutic markers for malignant lymphoma.
|
30358229 |
2019 |
|
stage, ovarian epithelial cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer.
|
30608899 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SOX30 regulated HCC progression through aberrant activation of p53 by directly binding to its promoter.
|
30312695 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SOX30 mRNA expression was quantified in bladder cancer tissue, paired adjacent normal tissue, and cell lines with qRT-PCR.
|
29880037 |
2018 |
|
Clear-cell metastatic renal cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the univariate Cox regression model, SOX1, SOX2, SOX6, SOX11, SOX12, SOX13, SOX15, SOX17 and SOX30 expression were predictive in the prognosis of clear cell RCC.
|
29541226 |
2018 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients.
|
30514297 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sox30 deficiency promotes lung metastasis in Sox30<sup>-/-</sup> mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression.
|
29739711 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma.
|
29855376 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
A chemical carcinogenic model of SOX30-knockout mice was generated to confirm the role of the SOX30-desmosomal gene axis in tumorigenesis.
|
29855376 |
2018 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, this study reveals that miR-645 can regulate oncogenesis in colon cancer with SOX30 being one of its targets.
|
28504690 |
2017 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |