Lung Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Lung Neoplasms
|
0.320 |
Therapeutic
|
group |
CTD_human |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Malignant neoplasm of lung
|
0.320 |
Therapeutic
|
disease |
CTD_human |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Malignant neoplasm of lung
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Indeed, blockade of p53 attenuates the tumor inhibition of SOX30.
|
25435374 |
2015 |
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of SOX30 induces cancer cell apoptosis with inhibiting proliferation in vitro and represses tumor formation in vivo, whereas knockdown of SOX30 demonstrates a reversed effect both in vitro and in vivo.
|
25435374 |
2015 |
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of SOX30 induces cancer cell apoptosis with inhibiting proliferation in vitro and represses tumor formation in vivo, whereas knockdown of SOX30 demonstrates a reversed effect both in vitro and in vivo.
|
25435374 |
2015 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, this study reveals that miR-645 can regulate oncogenesis in colon cancer with SOX30 being one of its targets.
|
28504690 |
2017 |
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, overexpression of SOX30 only moderately inhibited promotion of CRC cell proliferation by miR-645, indicating that miR-645 may have more targets that contribute to its pro-proliferation effect in colon cancer.
|
28504690 |
2017 |
Lung Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
In addition, knockout of SOX30 promotes lung tumor development and loss the inhibition of desmosomal genes on downstream Wnt and ERK signal in urethane-induced lung carcinogenesis in SOX30-knockout mice.
|
29855376 |
2018 |
Malignant neoplasm of lung
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, clinicopathological analyses showed that low SOX30 expression was positively related to an advanced tumor, node, and metastasis (TNM) stage.
|
29880037 |
2018 |
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of the expression of related desmosomal genes by miRNA significantly attenuated the inhibitory effect of SOX30 on cell proliferation, migration and invasion in vitro and on tumor growth and metastasis in vivo.
|
29855376 |
2018 |
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo.
|
29739711 |
2018 |
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Moreover, clinicopathological analyses showed that low SOX30 expression was positively related to an advanced tumor, node, and metastasis (TNM) stage.
|
29880037 |
2018 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene.
|
29880037 |
2018 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |