|
Lung Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
In addition, knockout of SOX30 promotes lung tumor development and loss the inhibition of desmosomal genes on downstream Wnt and ERK signal in urethane-induced lung carcinogenesis in SOX30-knockout mice.
|
29855376 |
2018 |
|
Malignant neoplasm of lung
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Lung Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
|
Lung Neoplasms
|
0.320 |
Therapeutic
|
group |
CTD_human |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
|
Malignant neoplasm of lung
|
0.320 |
Therapeutic
|
disease |
CTD_human |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
|
Malignant neoplasm of lung
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
SOX30 was expressed in normal and peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung cancer cell lines and primary lung tumor tissues harboring a hypermethylated SOX30.
|
25435374 |
2015 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Indeed, chemotherapy treatment containing platin or gemcitabine combined with SOX30 expression influences tumor cell metastasis and the survival of nude mice differently, which is closely associated with EMT.
|
30608899 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, clinicopathological analyses showed that low SOX30 expression was positively related to an advanced tumor, node, and metastasis (TNM) stage.
|
29880037 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of the expression of related desmosomal genes by miRNA significantly attenuated the inhibitory effect of SOX30 on cell proliferation, migration and invasion in vitro and on tumor growth and metastasis in vivo.
|
29855376 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
SOX30 expression is closely associated with histological types of NSCLC, and metastasis of adenocarcinoma (ADC) patients but not of squamous cell carcinoma (SCC) patients.
|
30514297 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo.
|
29739711 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Moreover, clinicopathological analyses showed that low SOX30 expression was positively related to an advanced tumor, node, and metastasis (TNM) stage.
|
29880037 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Indeed, blockade of p53 attenuates the tumor inhibition of SOX30.
|
25435374 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene.
|
29880037 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene.
|
29880037 |
2018 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
However, in early-stage SCC patients, SOX30 has no inhibitory role on tumor-metastasis due to not binding to CTNNB1 promoter leading to an unfavorable prognosis of the patients.
|
30514297 |
2018 |