|
Male infertility
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Deletion of Sox30 in mice uniquely impairs testis development and spermatogenesis with complete absence of spermatozoa in testes leading to male infertility, but does not influence ovary development and female fertility.
|
31835093 |
2020 |
|
Lung Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
In addition, knockout of SOX30 promotes lung tumor development and loss the inhibition of desmosomal genes on downstream Wnt and ERK signal in urethane-induced lung carcinogenesis in SOX30-knockout mice.
|
29855376 |
2018 |
|
Malignant neoplasm of lung
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In addition, nuclear SOX30 expression is closely associated with metastasis and represents a favorable independent prognostic biomarker of lung cancer patients.
|
29739711 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of the expression of related desmosomal genes by miRNA significantly attenuated the inhibitory effect of SOX30 on cell proliferation, migration and invasion in vitro and on tumor growth and metastasis in vivo.
|
29855376 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Indeed, blockade of p53 attenuates the tumor inhibition of SOX30.
|
25435374 |
2015 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits tumor cell metastasis in vitro and in vivo.
|
29739711 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene.
|
29880037 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In vitro proliferation, migration and invasion assays, and an in vivo nude mice model were utilized to assess the important role of desmosomal genes on SOX30-induced tumor suppression.
|
29855376 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
SOX30 strongly inhibits cancer cell migration and invasion in ADC cell lines, whrereas not affects cell migration and invasion in SCC cell lines.
|
30514297 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene.
|
29880037 |
2018 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
However, in early-stage SCC patients, SOX30 has no inhibitory role on tumor-metastasis due to not binding to CTNNB1 promoter leading to an unfavorable prognosis of the patients.
|
30514297 |
2018 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Functionally, SOX30 strongly inhibits tumor cell migration and invasion in intro, and suppresses tumor metastasis in vivo.
|
30608899 |
2019 |
|
Secondary Neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, Sox30 deficiency promotes tumor metastasis and reduces survival of mice.
|
29739711 |
2018 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression of desmosomal genes were upregulated by SOX30 in lung adenocarcinoma but not in lung squamous carcinoma.
|
29855376 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients.
|
30514297 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sox30 deficiency promotes lung metastasis in Sox30<sup>-/-</sup> mice and this uncontrollable lung-metastasis is re-inhibited upon Sox30 re-expression.
|
29739711 |
2018 |
|
Secondary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma.
|
29855376 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
A chemical carcinogenic model of SOX30-knockout mice was generated to confirm the role of the SOX30-desmosomal gene axis in tumorigenesis.
|
29855376 |
2018 |