Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we first investigate the possible association between the Val/Met polymorphism in COMT and bipolar disorder in the Han population, which has never been done before.
|
19578924 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response.
|
20004480 |
2010 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders.
|
20102619 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder.
|
20122740 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated SNPs across the whole COMT gene, including the Val(158)Met polymorphism, for a putative effect on working memory, executive function and IQ in 315 patients with schizophrenia or bipolar disorder and 340 healthy controls.
|
20605701 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.
|
20667170 |
2011 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism rs165599 in the COMT gene was associated with susceptibility to bipolar disorder (BD), mainly in women (AG: OR = 1.46; GG: OR = 1.84; P = 0.03).
|
21595525 |
2011 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes.
|
21600957 |
2011 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this paper, we review extant studies involving neurocognitive-genetic and neuroimaging-genetic perspectives and particularly related to catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin-1 (NRG1) genes in SZ and BD.
|
21688113 |
2011 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These studies suggest that DNA methylation analysis of MB-COMT promoter in saliva can potentially be used as an available epigenetic biomarker for disease state in SCZ and BD.
|
21820670 |
2011 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls.
|
22222175 |
2012 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Allele G from COMT SNPs rs4680 and rs165599 may represent reliable state-dependent predictors of global CD during manic and mixed episodes in BD.
|
22713126 |
2012 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
A gene coexpression network was developed based on a mutual information approach including four candidate genes (NRG1, DISC1, BDNF and COMT) along with other coexpressing genes in unipolar disorder, bipolar disorder and schizophrenia.
|
22777684 |
2012 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system.
|
23026378 |
2013 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load.
|
23421957 |
2013 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
|
23861766 |
2013 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Cognitive manic symptoms in bipolar disorder associated with polymorphisms in the DAOA and COMT genes.
|
23861766 |
2013 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study supports the hypothesis the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II(-AD) but not in BP-II(+AD).
|
25430946 |
2015 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function.
|
25744938 |
2015 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD.
|
25766270 |
2015 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects.
|
25766270 |
2015 |
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, the specific relevance of COMT enzymatic activity in the pathophysiology of BD and schizophrenia dimensions remains elusive.
|
27458023 |
2017 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data indicate a significant interaction between peripheral proline and COMT genotype, influencing negative symptoms in schizophrenia and bipolar disorder.
|
27622935 |
2016 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The catechol-O-methyltransferase (COMT) gene has been a candidate gene for BD.
|
27930497 |
2017 |