Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders.
|
20102619 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated SNPs across the whole COMT gene, including the Val(158)Met polymorphism, for a putative effect on working memory, executive function and IQ in 315 patients with schizophrenia or bipolar disorder and 340 healthy controls.
|
20605701 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response.
|
20004480 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the catechol-O-methyltransferase (COMT) gene has been significantly associated with risk for various neuropsychiatric conditions such as schizophrenia, panic disorder, bipolar disorders, anorexia nervosa and others.
|
18574484 |
2010 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we first investigate the possible association between the Val/Met polymorphism in COMT and bipolar disorder in the Han population, which has never been done before.
|
19578924 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The analysis of the COMT haplotypes revealed an association of the A-G haplotype with EPS risk in the overall group and the bipolar disorder subgroup, and an association of the A-A haplotype with EPS protection in the bipolar subgroup.
|
18922583 |
2008 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Findings support the COMT Val158Met polymorphism conferring vulnerability for different clinical phenotypes in schizophrenia and bipolar disorder.
|
18571901 |
2008 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations with the COMT polymorphism were absent in relatives of patients with bipolar disorder and control participants.
|
19025226 |
2008 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the COMT gene is associated with personality traits related to genetic risk for either schizophrenia or bipolar disorder, we examined dimensions of personality psychopathology in biological relatives of individuals with the disorders.
|
18201871 |
2008 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, COMT was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities.
|
16756688 |
2007 |
Bipolar Disorder
|
0.700 |
PosttranslationalModification
|
disease |
LHGDN |
These findings suggest that MB-COMT over-expression due to promoter hypomethylation and/or hyperactive allele of COMT may increase dopamine degradation in the frontal lobe providing a molecular basis for the shared symptoms of schizophrenia and bipolar disorder.
|
16984965 |
2006 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The COMT Val158Val genotype and serological evidence of infection with HSV-1 are independent risk factors for cognitive impairment in individuals with bipolar disorder, particularly in the domains of immediate and delayed memory.
|
16542182 |
2006 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Influence of the catechol-O-methyltransferase Val108/158Met polymorphism on the plasma concentration of catecholamine metabolites and on clinical features in type I bipolar disorder--a preliminary report.
|
16542735 |
2006 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltransferase (MB-COMT) due to altered promoter methylation and the nature of the contribution of COMT Val158Met polymorphism as risk factors for schizophrenia and bipolar disorder by analyzing 115 post-mortem brain samples from the frontal lobe.
|
16984965 |
2006 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MAOA and COMT genes may not influence suicidal behavior in patients with bipolar disorder.
|
15936529 |
2005 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A significant association between bipolar disorder and COMT polymorphisms was found.
|
15211633 |
2004 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
A significant association between bipolar disorder and COMT polymorphisms was found.
|
15211633 |
2004 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
The findings support the hypothesis that comorbid panic disorder identifies a genetic subtype of bipolar disorder and suggest a role for COMT and 5-HTT in vulnerability to these disorders.
|
11772685 |
2002 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
CTD_human |
Relative to the comparison subjects, subjects with bipolar disorder without panic disorder, but not those with comorbid bipolar disorder and panic disorder, showed significantly higher frequencies of the COMT Met158 and the short 5-HTTLPR alleles and genotypes.
|
11772685 |
2002 |
Bipolar Disorder
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
It has been suggested that a common functional genetic polymorphism in the COMT gene, which results in 3 to 4-fold difference in COMT enzyme activity, may contribute to the etiology of mental disorders such as bipolar disorder and alcoholism.
|
10395222 |
1999 |
Bipolar Disorder
|
0.700 |
Biomarker
|
disease |
BEFREE |
There is evidence implicating COMT as a candidate gene for a number of neuropsychiatric conditions including bipolar disorder.
|
9861640 |
1998 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our data support the hypothesis that variation in the COMT gene modifies the course of bipolar disorder.
|
9702744 |
1998 |
Bipolar Disorder
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder.
|
9264133 |
1997 |