COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder. 28049082 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder. 28102561 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]). 28544426 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 AlteredExpression disease BEFREE The methylation level of COMT and PPIEL gene is closely related to bipolar disorder. 29565503 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE These findings seem to indicate a role of COMT polymorphisms in regulating cognitive functioning in patients with BD. 30146088 2019