ADORA1, adenosine A1 receptor, 134

N. diseases: 121; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.200 Therapeutic phenotype RGD Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. 15220221 2004
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.010 Biomarker disease BEFREE To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH). 15257174 2004
CUI: C0013221
Disease: Drug toxicity
Drug toxicity 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug 		0.300 Biomarker group CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0242973
Disease: Ventricular Dysfunction
Ventricular Dysfunction 		0.300 Biomarker phenotype CTD_human Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? 15641640 2004
CUI: C0040822
Disease: Tremor
Tremor 		0.010 GeneticVariation phenotype BEFREE We tested mice with essential-like tremor using current drug therapies that alleviate symptoms in essential tremor patients (primidone, propranolol, and gabapentin) and several candidates hypothesized to reduce tremor, including ethanol; the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801; the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA); the GABA(A) receptor modulators diazepam, allopregnanolone, and Ro15-4513; and the L-type Ca2+ channel antagonist nitrendipine. 15765150 2005
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 Biomarker disease BEFREE Treatment of CML progenitor cells with the selective adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) resulted in a dose-dependent significant inhibition of clonogenic growth by 40% at a concentration of 10(-5) M, which could be reversed by the equimolar addition of the receptor agonist 2-chloro-N6-cyclopentyladenosine (P<0.05). 15806158 2005
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Influence of adenosine receptor agonists on benzodiazepine withdrawal signs in mice. 16226742 2005
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. 16256246 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.130 Biomarker disease BEFREE Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB). 16364194 2006
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.200 Biomarker disease RGD Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. 17067559 2006
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.010 AlteredExpression group LHGDN Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. 17088462 2006
CUI: C0242698
Disease: Ventricular Dysfunction, Left
Ventricular Dysfunction, Left 		0.200 Biomarker phenotype RGD Adenosine A1 receptor expression during the transition from compensated pressure overload hypertrophy to heart failure. 17211253 2007
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.010 AlteredExpression disease LHGDN Up-regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases. 18052973 2007
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.200 Biomarker group RGD Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats. 18307414 2008
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. 18313046 2008
CUI: C0428977
Disease: Bradycardia
Bradycardia 		0.300 Biomarker phenotype CTD_human Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. 18313046 2008
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.210 Biomarker disease RGD Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors. 18787037 2008
CUI: C0022116
Disease: Ischemia
Ischemia 		0.300 Biomarker phenotype CTD_human Adenosine A1 receptor (AR-A1) expression is increased following ischemia and may represent an endogenous neuroprotective effect. 18950269 2009
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.300 Biomarker disease CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0270192
Disease: Perinatal Subarachnoid Hemorrhage
Perinatal Subarachnoid Hemorrhage 		0.300 Biomarker phenotype CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009
CUI: C0472383
Disease: Subarachnoid Hemorrhage, Spontaneous
Subarachnoid Hemorrhage, Spontaneous 		0.300 Biomarker phenotype CTD_human Attenuation of cerebral vasospasm and secondary injury by 17beta-estradiol following experimental subarachnoid hemorrhage. 18950269 2009