Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-362-3p Targets PAX3 to Inhibit the Development of Glioma through Mediating Wnt/β-Catenin Pathway.
|
31167206 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used computational target gene prediction, <i>in vitro</i> cell culture, immunoblotting, quantitative real-time PCR, ATP measurements, luciferase reporter assays, wound-healing assays, Transwell assays, RNA immunoprecipitation PCR, co-immunoprecipitation, flow cytometry and tumor xenografts to study the regulation of the PKM2/β-catenin axis in glioma.
|
28858851 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing OIP5-AS1 reduced cell proliferation, invasion and migration of glioma U87 cells and led to depressed expression levels of miR-410, Wnt-7b, p-β-catenin, GSK-3β-pS9, c-Myc and cyclin D1.
|
30498093 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription.
|
20888802 |
2010 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we have demonstrated that Tcf-4 is associated with glioma progression and that AKT2 is a new member of the genes that are regulated by β-catenin/Tcf-4.
|
21636708 |
2011 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our experiment demonstrated the role of PAX3 in promoting glioma growth and development, possibly by interacting directly with β-catenin and regulating the Wnt signaling pathway.
|
30826985 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the Wnt/β-catenin pathway regulates glioma cell proliferation and invasion, in part via the EGFR pathway.
|
20969832 |
2010 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Meanwhile, Western blot was applied to explore whether HOXB7 can promote the progression of glioma through the Wnt/ β-catenin pathway.
|
30964174 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of WNT3a, cytoplasmic β-catenin and TCF4 was significantly associated with the histological malignancy grade and with a worse prognosis for patients with glioma.
|
26708597 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Wnt activity, evidenced by nuclear β-catenin in our cohort and high expression of its target AXIN2 (axis inhibitor protein 2) in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant.
|
26222502 |
2015 |
Glioma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast, enhanced expression of sFRPs inhibits the motility of glioma cells in vitro. sFRP-mediated effects on glioma cells are accompanied by decreased expression and activity of matrix metalloproteinase-2 (MMP-2) and decreased tyrosine phosphorylation of beta-catenin.
|
10980594 |
2000 |
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytokines related to glioma risk (P ≤ .05) more than 10 years before diagnosis are sIL10RB, VEGF, beta-Catenin and CCL22.
|
28594935 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Eps8 modulated the levels of phosphorylated extracellular signal-regulated protein kinase (ERK), phosphorylated serine-threonine protein kinase Akt and β-catenin expression in glioma cell lines and tissues.
|
23229386 |
2013 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation.
|
30373123 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Silencing EGFRvIII in U87Delta cultures with this virus reduced the expression of factors involved in epithelial-mesenchymal transition including N-cadherin, beta-catenin, Snail, Slug, and paxillin but not E-cadherin.
|
19001441 |
2008 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TIPE2 Inhibits Hypoxia-Induced Wnt/β-Catenin Pathway Activation and EMT in Glioma Cells.
|
27656836 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Down-regulation of USP9X also consistently inhibits the tumorigenicity of primary glioma cells in vivo.In summary, these results indicate that USP9X stabilizes β-catenin and activates Wnt/β-catenin signal pathway to promote glioma cell proliferation and survival.
|
27783990 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study validates a pathogenetic role of miR-19 in glioma and establishes a potentially regulatory and signaling involving miR-19 /RUNX3/β-catenin, also suggesting miR-19 may be a candidate therapeutic target in glioma.
|
29340016 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have shown that many molecular mechanisms, such as the EGFR, AKT, STAT3, and beta-catenin pathways, are involved in glioma.
|
24913705 |
2014 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-155 contributes to the progression of glioma by enhancing Wnt/β-catenin pathway.
|
25672607 |
2015 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression.
|
27713156 |
2016 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FOXK1 promotes cell growth through activating wnt/β-catenin pathway and emerges as a novel target of miR-137 in glioma.
|
30018719 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma.
|
26317904 |
2015 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lastly, β-catenin partially mediated the effect of YAP on glioma cell proliferation.
|
28962630 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study demonstrates that the inhibition of β-catenin in CSCs by Tet could be an effective strategy for the treatment of glioma.
|
27909720 |
2017 |