|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the ADRB2 gene has been hypothesized to have a role in differential response to beta-agonist (BA) therapy in asthma.
|
22158330 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the observed linkage to asthma in the 5q23-31 region is unrelated to variation in the beta(2)AR gene.
|
10934093 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the beta-2 adrenergic receptor in Israelis with severe asthma compared to non-asthmatic Israelis.
|
14650112 |
2003 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that genetic polymorphisms of the β(2)-adrenergic receptor (ADRβ(2)) are associated with intubation and mechanical ventilation in children with asthma.
|
22793522 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Herein, we focus on pharmacogenetic associations between genetic variants in the beta(2)-adrenergic receptor gene and bronchodilator response to albuterol among subjects with asthma.
|
18466098 |
2008 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.
|
10669529 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Clinical consequences of ADRbeta2 polymorphisms.
|
18303970 |
2008 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The extent of asthma's response to BD depends on the presence of polymorphisms in the ADRB2 gene.
|
22950544 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The influence of the AA 16 beta 2-adrenoceptor polymorphism on systemic and airway responses in asthma.
|
17292646 |
2008 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene.
|
16935688 |
2006 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Effect of ADRB2 (adrenergic receptor β2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma.
|
25985706 |
2015 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.
|
25111792 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ADRB2-c.16*AG is a risk factor (3.5-fold), while genotype GSDML-236*TT was protective (4-fold) for moderate-severe asthma.
|
25299150 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a South Indian population, the ADRB2 Arg/Gly may not form a susceptible variant to develop asthma nor can be a standard predictive marker to bronchodilator response; nevertheless, the patterns in asthma severity can be predicted by analyzing this variant.
|
26071206 |
2015 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pharmacogenetics of β2 adrenergic receptor gene polymorphisms, long-acting β-agonists and asthma.
|
21294785 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that ADCY9 gene polymorphisms may alone, and in combination with ADRB2 gene polymorphisms, contribute to individual response to combination therapy in mild to moderate asthmatics.
|
21545619 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Asthmatics were stratified by ADRB2 genotype in two studies to assess the effects of inhaled corticosteroids plus longacting beta2-agonists on asthma exacerbations.
|
18156033 |
2007 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In south Indian population, the ADRB2 Thr164Ile polymorphism may not form susceptible variant to develop asthma, however, it can form a predictive maker for bronchodilator (Salbutamol) response in severe asthmatics.
|
27450915 |
2016 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The primary hypothesis was that severe asthma exacerbations requiring hospital admission were associated with rare ADRB2 variants in patients receiving LABA therapy.
|
24621682 |
2014 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
With beta-agonists being the most widely used agents in the treatment of asthma, in vitro studies reported that beta(2)-adrenergic receptor (ADRB2) polymorphisms are associated with agonist-promoted down-regulation.
|
16164442 |
2005 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Many previous studies have investigated possible associations between polymorphisms in the ADRB2 gene and asthma, but have yielded conflicting results.
|
21801278 |
2011 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the polymorphisms of amino acids 16 and 27 of the beta2AR gene are not associated with the development of asthma per se, but that the Gly16 polymorphism may play a role in the pathogenesis of asthma severity.
|
10931116 |
2000 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The related papers on ADRB2 polymorphisms and asthma were systematically reviewed in databases of PubMed, EMBASE, Cochrane Library, and WanFang, Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were measured.
|
31115019 |
2019 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allele, genotype, and haplotype frequencies of the ADRB2 gene between asthmatic and non-asthmatic as well as demographic, clinical, and spirometric variables among asthmatic patients according to their genotype were compared.
|
22328447 |
2012 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma.
|
19514054 |
2009 |