|
Schizophrenia
|
0.900 |
PosttranslationalModification
|
disease |
BEFREE |
Neuregulin 1-induced AKT phosphorylation in monozygotic twins discordant for schizophrenia.
|
20371257 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue 1 (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population.
|
19747927 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The present results provide further evidence to support the AKT1 association with schizophrenia.
|
20421846 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
These deficits were related to SNPs from 16 genes, several previously associated with schizophrenia risk and/or involved in normal central nervous system development, including AKT, PI3K, SLC6A4, DRD2, CHRM2, and ADORA2A.
|
20691427 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Patients were genotyped for eight AKT1 Single Nucleotide Polymorphism (SNPs), which have been previously investigated for association with schizophrenia.
|
18635704 |
2009 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
However, minuscule data exist on the role of different alleles of AKT1 in measurable quantitative endophenotypes, such as cognitive abilities and neuroanatomical features, showing deviations in schizophrenia and bipolar disorder.
|
19051289 |
2009 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Supportive of an earlier tentative association of AKT1 with schizophrenia, we also found that this AKT1 variant was associated with risk for schizophrenia.
|
18497887 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Exploratory haplotype analysis confirmed association with schizophrenia toward the 5' end of AKT1 (.008 < p < .049, uncorrected).
|
17825267 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia sample of 193 Caucasians, 76 of which with TD.
|
18838251 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These data suggest that the SNPs in DRD2 and AKT1 may influence the treatment response to risperidone in schizophrenia patients.
|
18855532 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Variation in AKT1 has been associated with schizophrenia, bipolar disease and type II diabetes.
|
18395980 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric complications to influence risk for schizophrenia.
|
18195713 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia.
|
17464696 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Thus, our study does not indicate that AKT1 or DTNBP1 play a role in the etiology of schizophrenia in the Finnish population.
|
17300918 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder.
|
17233643 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.Nat.Genet.
|
17383860 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.
|
17915974 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.
|
17915974 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings did not confirm the association of AKT1 SNP2/3/4 TCG haplotype with the risk of schizophrenia as reported in the original study but showed the evidence of association with a different haplotype, AKT1 five-SNP AGCAG haplotype, with the risk of schizophrenia in Iranian population.
|
16583435 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
|
16395129 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
For other genes, disrupted in schizophrenia (DISC1), D-amino acid oxidase activator (DAOA), regulator of G-protein signalling 4 (RGS4) and V-AKT murine thymoma viral oncogene homolog 1 (AKT1) the data are promising but not yet compelling.
|
16612196 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
A family based association test of AKT1 did not show association with schizophrenia in Japanese subjects.
|
16987250 |
2006 |