|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Several publications support the implication of AKT1 in disorders of the dopaminergic system including bipolar disease and schizophrenia.
|
21741444 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Recent investigations suggest that the AKT/glycogen synthase kinase 3 (GSK3) signaling cascade may be associated with the pathophysiology of schizophrenia and methamphetamine (METH) use disorder.
|
17233643 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia.
|
28467426 |
2017 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Patients with schizophrenia displayed decreased AKT but normal ERK ratio compared with controls.
|
22209534 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Patients were genotyped for eight AKT1 Single Nucleotide Polymorphism (SNPs), which have been previously investigated for association with schizophrenia.
|
18635704 |
2009 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.
|
17915974 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.
|
17915974 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia.
|
15522255 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
LHGDN |
Our study provides support for the theory that AKT1 is a susceptibility gene for Japanese schizophrenia.
|
15522255 |
2004 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a genetic variant of AKT1 might be associated with attentional deficits and brain morphological vulnerability in patients with schizophrenia.
|
22150081 |
2013 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that AKT1 affects risk for schizophrenia and accompanying cognitive deficits, at least in part through specific genetic interactions related to brain neuroplasticity and development, and that these AKT1 effects may be pharmacologically modulated in patients.
|
21788944 |
2012 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our findings did not confirm the association of AKT1 SNP2/3/4 TCG haplotype with the risk of schizophrenia as reported in the original study but showed the evidence of association with a different haplotype, AKT1 five-SNP AGCAG haplotype, with the risk of schizophrenia in Iranian population.
|
16583435 |
2006 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
No association between AKT1 gene variants and schizophrenia: a Malaysian case-control study and meta-analysis.
|
23747160 |
2013 |
|
Schizophrenia
|
0.900 |
PosttranslationalModification
|
disease |
BEFREE |
Neuregulin 1-induced AKT phosphorylation in monozygotic twins discordant for schizophrenia.
|
20371257 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Most exciting have been recent associations of schizophrenia with specific genes, such as neuregulin-1, dysbindin-1, and AKT-1, which are vital to synaptic development, neurotransmission, and plasticity.
|
15581715 |
2005 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Many susceptible genes have been identified in schizophrenia such as catechol-O-methyltransferase (COMT) and serine/threonine kinase (AKT1).
|
25801838 |
2015 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, our aim was to determine whether AKT1 gene variants are associated with particular phenotypes for schizophrenia (SCZ) and bipolar disorder (BPD).
|
22277669 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In the context of anti-psychotic drugs, the DRD2 and AKT1 polymorphisms altered dose-response effects of anti-psychotic drugs on cognition in schizophrenia (n = 111).
|
22525159 |
2012 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue 1 (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population.
|
19747927 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions.
|
15982448 |
2006 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings, by showing the involvement of the AKT1 gene in both schizophrenia and bipolar disorder, support the role of AKT1 in the genetics of both disorders and add support to the view that there is some genetic overlap between them.
|
20214684 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
However, minuscule data exist on the role of different alleles of AKT1 in measurable quantitative endophenotypes, such as cognitive abilities and neuroanatomical features, showing deviations in schizophrenia and bipolar disorder.
|
19051289 |
2009 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes.
|
23246288 |
2013 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Genetic linkage and association studies have identified Akt-1 as a candidate susceptibility gene related for schizophrenia.
|
22771711 |
2012 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
For other genes, disrupted in schizophrenia (DISC1), D-amino acid oxidase activator (DAOA), regulator of G-protein signalling 4 (RGS4) and V-AKT murine thymoma viral oncogene homolog 1 (AKT1) the data are promising but not yet compelling.
|
16612196 |
2006 |