|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised.
|
25982579 |
2016 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
P values of less than 0.05 were considered to represent statistically significant associations between glucocorticoid receptor gene polymorphisms and asthma.
|
29729712 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
|
18952539 |
2008 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma.
|
8018337 |
1994 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress.
|
31079340 |
2019 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The N363S polymorphism of NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of moderate to severe form of uncontrolled bronchial asthma.
|
22015776 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the G allele at rs41423247 of the glucocorticosteroid receptor (NR3C1) gene is associated with a higher improvement in FEV1 at 4 h in children with moderate-to-severe asthma exacerbation treated with high-dose ICS.
|
27003716 |
2016 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was no significant difference between the I559N and V729I GR variants on comparing SR asthma patients with SS asthma patients or CTRs.
|
25815773 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Gene mutations that are known to alter the response to asthma therapy include Arg/Arg atr position 16, mutations of LTC4S, ALOX5, and GR/NR3C1, increased expression of GR , CRHR1 variants, and mutations in CYP1A2 (-22964 [G/A]), and T 314 allele for histamine N-methyltransferase.
|
17672811 |
2007 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recently a causative role for a splicing variant of the glucocorticoid receptor (hGR beta) has been proposed in glucocorticoid resistance in asthma and ulcerative colitis, whereas another splicing variant (hGR P) might be associated with glucocorticoid-resistant haematological malignancies.
|
15635817 |
2004 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The Bcl I polymorphism of h-GR/NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of severe form and resistance to GCs in Polish population.
|
21113676 |
2011 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this research project was to study the correlation between the N363S and I559N polymorphisms of the h-GR/NR3C1 gene and the occurrence of asthma in a population of Polish asthmatics.
|
22469783 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In patients with severe asthma, several molecular mechanisms have been identified that might account for reduced steroid responsiveness, including reduced nuclear translocation of glucocorticoid receptor (GR) α after binding corticosteroids.
|
23360759 |
2013 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, SNPs in NR3C1 were not significantly associated with asthma in patients from the Henan Province.
|
27323143 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD5423 is a non-steroidal glucocorticoid receptor modulator, with low aqueous solubility, developed for treatment of asthma and COPD.
|
28281196 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma.
|
26635083 |
2015 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We reasoned that, because many cytokine genes activated in asthma are transcriptionally regulated by the recruitment of this complex to DNA, their binding sites might provide a target for GR to mediate its repressive effects.
|
15826950 |
2005 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We examined whether the bacterial product lipopolysaccharide (LPS) reduces glucocorticoid receptor (GR) function in control nasal mucosa (NM) fibroblasts and in nasal polyp (NP) fibroblasts from patients with CRSwNP and asthma.
|
25943109 |
2015 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor (GR)-α phosphorylated at serine 226 was increased in cells from severe asthma, and the MUC1-CT/GRα complex was downregulated in severe asthma cells.
|
29978485 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that delivery of the GR gene in vivo may reduce inflammation without recourse to GC and may constitute an alternative therapeutic approach for corticoresistant asthma.
|
10435109 |
1999 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These GCR changes along with recent evidence for increased transcription factor activation in SR asthma which may inhibit GCR/DNA interactions as well as the selective recruitment of neutrophils into the airways of certain patients with severe asthma contribute to the heterogeneity of mechanisms underlying steroid resistance.
|
9560836 |
1998 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To evaluate expression and interaction of HDACs with glucocorticoid receptor isoforms in bronchoalveolar lavage and peripheral blood mononuclear cells from steroid-resistant versus steroid-sensitive patients with asthma.
|
20538962 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Unstimulated peripheral blood mononuclear cells (PBMCs) from corticosteroid-resistant (CR) but not corticosteroid-sensitive (CS) asthmatics demonstrate increased activating peptide-1 (AP-1)- and decreased glucocorticoid receptor (GR)-DNA binding.
|
9854051 |
1998 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated whether the incapacity of GC to inhibit production of these cytokines in vivo was the result of a dysregulation of the glucocorticoid receptor (GR) in GC-dependent asthma.
|
10903212 |
2000 |