|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.
|
22156779 |
2012 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised.
|
25982579 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.
|
7500041 |
1995 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD5423 is a non-steroidal glucocorticoid receptor modulator, with low aqueous solubility, developed for treatment of asthma and COPD.
|
28281196 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD7594 is a non-steroidal, selective, glucocorticoid receptor modulator (SGRM), currently in development for the treatment of asthma and chronic obstructive pulmonary disease.
|
31814707 |
2019 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma.
|
8018337 |
1994 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chronic stress has also been shown to result in biological changes such as expression of immunologic genes, changes in expression of the beta-adrenergic (B2AR) and the glucocorticoid receptor (GR-α) genes, cytokine regulation, and alterations in the hypothalamic pituitary axis and cortisol levels which all may affect asthma pathophysiology and therapeutic response among patients exposed to chronic stress.
|
31079340 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compared with PBMCs from patients with easy-to-control asthma, PBMCs from those with difficult-to-control asthma had significantly lower glucocorticoid receptor α levels at V0 (P = .05).
|
30059697 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
DEX-stimulated recruitment of GR and histone H4 acetylation at the glucocorticoid response element 4.6 kbp upstream of the MKP-1 gene were significantly lower in monocytes from patients with SR asthma compared with those from patients with SS asthma.
|
24418482 |
2014 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Excluding noncompliance with GC treatment, abnormal steroid pharmacokinetics, and rare genetic defects in the glucocorticoid receptor (GR), the majority of GC insensitivity in asthma can be attributed to secondary defects related to GR function.
|
24162914 |
2014 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma.
|
12400872 |
2002 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
|
9348314 |
1997 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GCs after binding to the glucocorticoid receptor (GR) form the complex (transcription factor), which acts on promoter and regulatory parts of genes enhancing the expression of anti-inflammatory proteins and decreasing the proinflammatory protein synthesis, including numerous cytokines mediating inflammation in the course of asthma.
|
25649164 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Gene mutations that are known to alter the response to asthma therapy include Arg/Arg atr position 16, mutations of LTC4S, ALOX5, and GR/NR3C1, increased expression of GR , CRHR1 variants, and mutations in CYP1A2 (-22964 [G/A]), and T 314 allele for histamine N-methyltransferase.
|
17672811 |
2007 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
|
25863981 |
2015 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GLCCI1 deficiency in asthmatic mice inhibits the activation of GR and MKP-1 and leads to more obvious phosphorylation of p38 MAPK, leading to a decremental sensitivity to GCs.
|
30511684 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor (GR)-α phosphorylated at serine 226 was increased in cells from severe asthma, and the MUC1-CT/GRα complex was downregulated in severe asthma cells.
|
29978485 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma.
|
30704470 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids activated the glucocorticoid receptor and inhibited serum-induced secretion of interleukin-6 in bronchial smooth-muscle cells from both subjects with asthma and those without asthma; however, glucocorticoids inhibited proliferation only in bronchial smooth-muscle cells from subjects without asthma.
|
15295049 |
2004 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma.
|
26635083 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the G allele at rs41423247 of the glucocorticosteroid receptor (NR3C1) gene is associated with a higher improvement in FEV1 at 4 h in children with moderate-to-severe asthma exacerbation treated with high-dose ICS.
|
27003716 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, interactions between residential greenspace and difficult family relationships were found for asthma control (<i>P</i> = .02), asthma functional limitations (<i>P</i> = .04), airway inflammation (<i>P</i> = .007), and the abundance of glucocorticoid receptor in T-helper cells (<i>P</i> = .05).
|
28280210 |
2017 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the relationship between airway eosinophilia and the expression of FK506-binding protein 51 (FKBP51), a glucocorticoid receptor co-chaperone that plays a role in steroid insensitivity in asthma, remains unknown.
|
23762334 |
2013 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Impaired GRα nuclear translocation and inhibited p-p65 expression might contribute to glucocorticoid resistance caused by MUC1 deficiency in TNF-α-induced necroptosis in 16HBE cells, and should be considered as a potential target for the development of novel therapeutics for asthma.
|
30738043 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Impaired nuclear entry of GR has been documented in steroid-non-responsive asthmatics.
|
19619331 |
2009 |