|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
DEX-stimulated recruitment of GR and histone H4 acetylation at the glucocorticoid response element 4.6 kbp upstream of the MKP-1 gene were significantly lower in monocytes from patients with SR asthma compared with those from patients with SS asthma.
|
24418482 |
2014 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In a sample of 104 youth with asthma (10-17 years) and their primary caregiver, we assessed SES via caregiver report, emotional expression by youth and parents in the home over four days using the electronically activated recorder (EAR), and NR3C1 expression via blood collected from youth.
|
29529520 |
2018 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
AZD5423 is a non-steroidal glucocorticoid receptor modulator, with low aqueous solubility, developed for treatment of asthma and COPD.
|
28281196 |
2017 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.
|
22156779 |
2012 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma.
|
26635083 |
2015 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A relationship between single nucleotide polymorphism in the glucocorticoid receptor (GCR) gene promoter (Bcl I polymorphism), development of asthma and sensitivity to glucocorticoids has been hypothesised.
|
25982579 |
2016 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We reasoned that, because many cytokine genes activated in asthma are transcriptionally regulated by the recruitment of this complex to DNA, their binding sites might provide a target for GR to mediate its repressive effects.
|
15826950 |
2005 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We examined whether the bacterial product lipopolysaccharide (LPS) reduces glucocorticoid receptor (GR) function in control nasal mucosa (NM) fibroblasts and in nasal polyp (NP) fibroblasts from patients with CRSwNP and asthma.
|
25943109 |
2015 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoid receptor (GR)-α phosphorylated at serine 226 was increased in cells from severe asthma, and the MUC1-CT/GRα complex was downregulated in severe asthma cells.
|
29978485 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The localization of GR mRNA and protein to specific cell types within lung and airway will make it possible to study the cellular targets of glucocorticoid therapy in inflammatory lung diseases such as asthma.
|
8810618 |
1996 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Secondary steroid resistance in asthma may arise in response to the release of cytokines that activate AP-1 and other transcription factors that bind directly to GR.
|
7633872 |
1995 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that delivery of the GR gene in vivo may reduce inflammation without recourse to GC and may constitute an alternative therapeutic approach for corticoresistant asthma.
|
10435109 |
1999 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These GCR changes along with recent evidence for increased transcription factor activation in SR asthma which may inhibit GCR/DNA interactions as well as the selective recruitment of neutrophils into the airways of certain patients with severe asthma contribute to the heterogeneity of mechanisms underlying steroid resistance.
|
9560836 |
1998 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
|
25863981 |
2015 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
P values of less than 0.05 were considered to represent statistically significant associations between glucocorticoid receptor gene polymorphisms and asthma.
|
29729712 |
2018 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma.
|
16567656 |
2006 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
|
18952539 |
2008 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
GLCCI1 deficiency in asthmatic mice inhibits the activation of GR and MKP-1 and leads to more obvious phosphorylation of p38 MAPK, leading to a decremental sensitivity to GCs.
|
30511684 |
2018 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma.
|
8018337 |
1994 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To evaluate expression and interaction of HDACs with glucocorticoid receptor isoforms in bronchoalveolar lavage and peripheral blood mononuclear cells from steroid-resistant versus steroid-sensitive patients with asthma.
|
20538962 |
2010 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling.
|
31477204 |
2019 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compared with PBMCs from patients with easy-to-control asthma, PBMCs from those with difficult-to-control asthma had significantly lower glucocorticoid receptor α levels at V0 (P = .05).
|
30059697 |
2019 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Unstimulated peripheral blood mononuclear cells (PBMCs) from corticosteroid-resistant (CR) but not corticosteroid-sensitive (CS) asthmatics demonstrate increased activating peptide-1 (AP-1)- and decreased glucocorticoid receptor (GR)-DNA binding.
|
9854051 |
1998 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated whether the incapacity of GC to inhibit production of these cytokines in vivo was the result of a dysregulation of the glucocorticoid receptor (GR) in GC-dependent asthma.
|
10903212 |
2000 |