|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.
|
7500041 |
1995 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Secondary steroid resistance in asthma may arise in response to the release of cytokines that activate AP-1 and other transcription factors that bind directly to GR.
|
7633872 |
1995 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Chemical mutational analysis of the human glucocorticoid receptor cDNA in glucocorticoid-resistant bronchial asthma.
|
8018337 |
1994 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The localization of GR mRNA and protein to specific cell types within lung and airway will make it possible to study the cellular targets of glucocorticoid therapy in inflammatory lung diseases such as asthma.
|
8810618 |
1996 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
|
9348314 |
1997 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These GCR changes along with recent evidence for increased transcription factor activation in SR asthma which may inhibit GCR/DNA interactions as well as the selective recruitment of neutrophils into the airways of certain patients with severe asthma contribute to the heterogeneity of mechanisms underlying steroid resistance.
|
9560836 |
1998 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Unstimulated peripheral blood mononuclear cells (PBMCs) from corticosteroid-resistant (CR) but not corticosteroid-sensitive (CS) asthmatics demonstrate increased activating peptide-1 (AP-1)- and decreased glucocorticoid receptor (GR)-DNA binding.
|
9854051 |
1998 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We sought to determine the in vivo modulation of GR mRNA expression by fluticasone propionate (FP) in subjects with mild asthma.
|
10200007 |
1999 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data suggest that delivery of the GR gene in vivo may reduce inflammation without recourse to GC and may constitute an alternative therapeutic approach for corticoresistant asthma.
|
10435109 |
1999 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated whether the incapacity of GC to inhibit production of these cytokines in vivo was the result of a dysregulation of the glucocorticoid receptor (GR) in GC-dependent asthma.
|
10903212 |
2000 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
While incubated with combination of IL-2 and IL-4, a significantly higher expression of GR mRNA was observed in all asthmatics, and a significantly higher expression of HSP90 mRNA was observed only in SS and SD patients.
|
11677765 |
2001 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
LHGDN |
[Response to glucocorticoid treatment in asthma. The role of alpha and beta isoforms of the glucocorticoid receptor].
|
12237016 |
2002 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression of c-fos, rather than c-jun or glucocorticoid-receptor mRNA, correlates with decreased glucocorticoid response of peripheral blood mononuclear cells in asthma.
|
12400872 |
2002 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids activated the glucocorticoid receptor and inhibited serum-induced secretion of interleukin-6 in bronchial smooth-muscle cells from both subjects with asthma and those without asthma; however, glucocorticoids inhibited proliferation only in bronchial smooth-muscle cells from subjects without asthma.
|
15295049 |
2004 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Recently a causative role for a splicing variant of the glucocorticoid receptor (hGR beta) has been proposed in glucocorticoid resistance in asthma and ulcerative colitis, whereas another splicing variant (hGR P) might be associated with glucocorticoid-resistant haematological malignancies.
|
15635817 |
2004 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We reasoned that, because many cytokine genes activated in asthma are transcriptionally regulated by the recruitment of this complex to DNA, their binding sites might provide a target for GR to mediate its repressive effects.
|
15826950 |
2005 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma.
|
16387802 |
2006 |
|
Asthma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma.
|
16567656 |
2006 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Gene mutations that are known to alter the response to asthma therapy include Arg/Arg atr position 16, mutations of LTC4S, ALOX5, and GR/NR3C1, increased expression of GR , CRHR1 variants, and mutations in CYP1A2 (-22964 [G/A]), and T 314 allele for histamine N-methyltransferase.
|
17672811 |
2007 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Understanding the molecular mechanisms of GR action and inaction may lead to the development of new anti-inflammatory drugs or enable clinicians to reverse the relative steroid-insensitivity that is characteristic of some patients with severe asthma.
|
18417060 |
2008 |
|
Asthma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
|
18952539 |
2008 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Impaired nuclear entry of GR has been documented in steroid-non-responsive asthmatics.
|
19619331 |
2009 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To evaluate expression and interaction of HDACs with glucocorticoid receptor isoforms in bronchoalveolar lavage and peripheral blood mononuclear cells from steroid-resistant versus steroid-sensitive patients with asthma.
|
20538962 |
2010 |
|
Asthma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In males, no change to cortisol, birth weight or placental GR were evident in pregnancies with asthma.
|
20627904 |
2010 |