|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Diverse proteomic alterations in gastric adenocarcinoma.
|
15378696 |
2004 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Irreversible aggregation of protein synthesis machinery after focal brain ischemia.
|
16805800 |
2006 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Assembly of proteins to postsynaptic densities after transient cerebral ischemia.
|
9425004 |
1998 |
|
Graft-vs-Host Disease
|
0.200 |
Biomarker
|
disease |
RGD |
Expression of 70-kDa heat-shock protein during acute graft-versus-host disease.
|
9557158 |
1998 |
|
Liver Failure, Acute
|
0.200 |
Biomarker
|
disease |
RGD |
Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage.
|
15270078 |
2004 |
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
73-kDa molecular chaperone HSP73 is a direct target of antibiotic gentamicin.
|
14966137 |
2004 |
|
Paraneoplastic Syndromes, Ocular
|
0.200 |
Biomarker
|
disease |
RGD |
Cancer-associated retinopathy induced by both anti-recoverin and anti-hsc70 antibodies in vivo.
|
10586938 |
1999 |
|
Chemical and Drug Induced Liver Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Immunohistochemical studies on the expression pattern of molecular chaperones HSC70 and HSP25 and cell cycle-related proteins cyclin D1 and PCNA in rat liver after thioacetamide intoxication.
|
12376827 |
2002 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Somatic mutations of 11q23.3-linked constitutive heat shock protein 70 gene (HSPA8 alias HSC70) are detected by others in breast carcinomas.
|
14991745 |
2004 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer.
|
29510992 |
2018 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In both cases, mutation was coincident with allelic imbalance, suggesting that HSC70 is a target of somatic mutation and deletion in a fraction of breast carcinomas.
|
10485459 |
1999 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of Hsp70 protein expression, and its close family member, Hsc70, on breast cancer cell viability and on the activity of the Hsp90/Hsp70 chaperone complex, a complex whose activity is important for the survival of cancer cells and tumours.
|
17487411 |
2007 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
|
19800331 |
2009 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
A significant downregulation of HSPA8 and HSPA9 was observed in AD across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis.
|
23948933 |
2014 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we report the interaction between the human Hsp70 isoform heat shock cognate 71-kDa protein (Hsc70 or HSPA8) and peptides derived from the microtubule-associated protein Tau, which is linked to Alzheimer's disease.
|
29764935 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The expression levels of the chaperone-mediated autophagy proteins LAMP2A and hsc70 were significantly reduced in the substantia nigra pars compacta and amygdala of PD brains compared with age-matched AD and control brain samples.
|
20697033 |
2010 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the effects of a small-molecule HSC70 inhibitor, VER-155008, on axonal morphology and memory function in a mouse model of AD (5XFAD mice).
|
29441022 |
2018 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Our study indicated that reducing the HSC70 level is a new possible therapeutic target of axonal regeneration in AD.
|
30076345 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
|
19800331 |
2009 |
|
Malignant neoplasm of breast
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
HSP70-2 P1/P2, HSPA8 intronic 1541-1542delGT and HIF-1 alpha polymorphisms were not associated with breast cancer risk, as evidenced by the dose-response allele models.
|
23065205 |
2012 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer.
|
29510992 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of Hsp70 protein expression, and its close family member, Hsc70, on breast cancer cell viability and on the activity of the Hsp90/Hsp70 chaperone complex, a complex whose activity is important for the survival of cancer cells and tumours.
|
17487411 |
2007 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Hsc70 appears active in human breast cancer cells and hypersecreted by direct cath D inhibition.
|
19802014 |
2010 |