|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the apolipoprotein B-100 gene (APOB) can result in a phenotype that is clinically indistinguishable from familial hypercholesterolemia, and mutations in this gene have also been shown to be associated with coronary heart disease.
|
15321838 |
2004 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast, neither levels of cholesterol, LDL cholesterol, apolipoprotein B, or triglycerides, nor risk of ischaemic heart disease was associated with genotype.
|
15172466 |
2004 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease.
|
12752570 |
2003 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample.
|
12640502 |
2003 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels that is associated with mutations in the genes LDLR (encoding low-density lipoprotein receptor) or APOB (encoding apolipoprotein B).
|
12730697 |
2003 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cholesteryl ester transfer protein facilitates the exchange of neutral lipids between HDL and apolipoprotein B containing lipoproteins, which hold powerful opposing roles as risk factors for coronary artery disease.
|
12642786 |
2003 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The haplotype analyses using multiple markers of the apolipoprotein B gene in patients with coronary artery disease.
|
11748351 |
2001 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single effects of apolipoprotein B, (a), and E polymorphisms and interaction between plasminogen activator inhibitor-1 and apolipoprotein(a) genotypes and the risk of coronary artery disease in Czech male caucasians.
|
10720441 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to detect mutations in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in patients of Southeast Asian origin with clinically diagnosed familial hypercholesterolemia (FH) and to relate these findings with the observed lower incidence of coronary heart disease in this part of the world.
|
11005141 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Angiotensin-converting enzyme and apolipoprotein B polymorphisms in coronary artery disease.
|
10781757 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases.
|
11096445 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Familial defective apolipoprotein (apo) B-100 is an autosomal codominant disorder associated with hypercholesterolemia and an increased risk of coronary artery disease.
|
11028773 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of the apolipoprotein B gene polymorphisms with cholesterol levels and response to fluvastatin in Brazilian individuals with high risk for coronary heart disease.
|
11071065 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results, that associate overexpression of fibrinogen with enhance apolipoprotein B secretion, may be significant since epidemiological studies indicate that elevated levels of fibrinogen and lipids are independent risk factors in coronary artery disease.
|
10873614 |
2000 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Evolution of the apolipoprotein B gene and coronary artery disease: a study in low and high risk Asians.
|
10738520 |
1999 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Since the apoB plasma level was not only associated with the apoB SP Ins/Del gene variation but also to the extent of coronary artery disease (P <0.0001), individuals with an InsIns genotype and without CAD had the lowest and subjects with a DelDel genotype and triple vessel disease the highest apoB plasma levels (P <0.0001).
|
9863550 |
1998 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the apolipoprotein B 3' variable number of tandem repeats region associated with coronary artery disease in Taiwanese.
|
9585673 |
1998 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the LDL receptor (LDLR) or the apolipoprotein B-100 genes causing familial hypercholesterolemia (FH) and familial defective apolipoprotein B-100 (FDB), two of the most frequent inherited diseases, are the underlying genetic defects in a small proportion of patients suffering from premature atherosclerotic heart disease.
|
9727746 |
1998 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The XbaI, EcoRI and the signal peptide insertion/deletion (I/D) polymorphic sites of APOB gene, the CfoI polymorphic site of apolipoprotein E gene (APOE), and the insertion/deletion polymorphism of angiotensin I-converting enzyme (ACE) gene were studied using polymerase chain reaction (PCR) in 55 postmenopausal women with coronary artery disease (CAD) and in 119 control women of equivalent age.
|
9298741 |
1997 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation of the apolipoprotein B gene in Korean patients with coronary artery disease.
|
9339897 |
1997 |
|
Coronary Arteriosclerosis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B, fibrinogen, HDL cholesterol, and apolipoprotein(a) phenotypes predict coronary artery disease in hemodialysis patients.
|
9402091 |
1997 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied triglycerides, retinyl palmitate and squalene and apolipoprotein B-48 after a fat loading test in one subject heterozygous for a novel point mutation of apolipoprotein A-I (A-IFIN, Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease, and in 16 healthy controls with the same apolipoprotein E phenotype, 3/3, as the proband.
|
9125314 |
1996 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms of the apolipoprotein B gene with coronary heart disease in Han Chinese.
|
8546754 |
1995 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions.
|
8530010 |
1995 |
|
Coronary Arteriosclerosis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Elevated plasma levels of apolipoprotein B (apoB)-containing lipoproteins constitute a major risk factor for the development of coronary heart disease.
|
8533758 |
1995 |