|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TRIM14 was recently reported as a key molecule in the IFN-signaling pathway that regulates IFN production in response to viral infection.
|
30150992 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP.
|
29990995 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms in these genes may cause chronic dysregulated IFN signaling in islets, characterized by hyperexpression of IFN-I, the IFN gene signature, and major histocompatibility complex class I during viral infection.
|
29369915 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We also found that the antiviral effector 2-5A-dependent endoribonuclease, which is not an ISG in humans, is highly IFN inducible in black flying fox cells and contributes to cell-intrinsic control of viral infection.
|
29180486 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of IFN-λ in the airway is impaired in chronic airway diseases (e.g., asthma, chronic obstructive pulmonary disease), which renders patients susceptible to viral infection.
|
30224514 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite its beneficial effects in viral infections IFNα has been reported to be associated with several autoimmune diseases including autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis, primary biliary cholangitis, and recently emerged as a major cytokine that triggers Type 1 Diabetes.
|
30115527 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Innate immune responses elicited by Sin Nombre virus or type I IFN agonists protect hamsters from lethal Andes virus infections.
|
30067171 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The contribution of distinct central nervous system (CNS) resident cells to protective alpha/beta interferon (IFN-α/β) function following viral infections is poorly understood.
|
29491163 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A detailed immunological investigation of these patients revealed impaired responses to type I IFN, IL-10, IL-12 and IL-23, which are associated with increased susceptibility to mycobacterial and/or viral infections.
|
29725107 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFN-stimulated gene expression establishes the antiviral state, limiting viral infection in IFN-α-stimulated microenvironments.
|
30282499 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review we summarize the recent findings on the role of individual IFNα subtypes during HIV and Simian Immunodeficiency Virus infection.
|
29475588 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type III IFN (IFN-λ) is the dominant frontline response over type I IFN in human normal intestinal epithelial cells upon viral infection, this response being mimicked by the dsRNA analog poly-IC.
|
30349642 |
2018 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of TBK1_tv1 and TBK1_tv2 inhibits RIG-I-, MAVS-, TBK1-, and IRF3-mediated activation of IFN promoters in response to spring viremia of carp virus infection.
|
29441066 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IFNL polymorphisms influence regulatory pathways of cellular response to IFN and affect body iron balance in chronic hepatitis C virus infection.
|
27125837 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses.
|
28289095 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the results illustrate the functional significance of the SPL-IKKε-IFN axis during host innate immunity against viral infection.
|
28600291 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, recombinant IFN-λ has therapeutic potential against enteric viral infections, many of which lack other effective treatments.
|
28713375 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Type III interferons (IFN-λ) control enteric viral infections in the gut and have been shown to cure mouse norovirus, a small-animal model for HNoVs.
|
28077655 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upon virus infection, host cells use retinoic-acid-inducible geneI I (RIG-I)-like receptors to recognize viral RNA and activate type I IFN expression.
|
28011935 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We show here that miR-21 is an essential positive regulator for the production of both IFN-α and IFN-λ by pDCs and for promoting host defense against viral infection. miR-21 was markedly upregulated in toll-like receptor (TLR)-activated pDCs and was crucial for TLR7/9 ligand- or herpesvirus-induced production of IFN-α and IFN-λ by pDCs. miR-21-deficient pDCs produced significantly lower levels of IFN-α and IFN-λ on activation than those by wild-type pDCs.
|
28871250 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Inhibition of PML-NB formation by blocking IFN pathway or silencing PML expression resulted in a significant reduction of RSV-associated NRF2 degradation and increased antioxidant enzyme expression, identifying the RNF4-PML pathway as a key regulator of antioxidant defenses in the course of viral infection.
|
29107745 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The type I IFN response quickly became associated with its role in the innate immune response to viral infection.
|
28580319 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection.
|
28793350 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection.
|
28603526 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings highlight the role of fetal/placental IFN in the modulation of viral infection in the mother and fetus.
|
28264970 |
2017 |