|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, among those with amyloid-associated depression, ApoE4 carriers tended to have a higher risk of AD than ApoE4 non-carriers (40% vs. 4%, p = 0.06).
|
26250797 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; however, the precise molecular mechanism through which ApoE4 influences the risk of disease development remains unknown.
|
27406263 |
2016 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed additive interactions between APOE ε4 and depression (joint effect HR = 2.21; 95% CI = 1.24-3.91; test for additive interaction, p < 0.001); and between APOE ε4 and apathy (joint effect HR = 1.93; 95% CI = 0.93-3.98; test for additive interaction, p = 0.031).
|
25653291 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.
|
25670333 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the APOE*E4 allele predicted future depression in this Swedish population study, even after excluding depressed individuals who later developed dementia, suggesting that the APOE*E4 allele could potentially identify people at high risk for clinically significant depression.
|
25708227 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data support the safety of condensed protocols for APOE disclosure for those free of severe anxiety or depression who are actively seeking such information.
|
25499536 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was no interaction between depression and APOE on cognition (p > .05).
|
26035038 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used logistic regression to investigate the association between the combined scores from these two items and cognitive health at follow-up, while adjusting for several health and life-style variables from midlife and for apolipoprotein E4 (ApoE4) status, depression and hopelessness feelings at follow-up.
|
26460971 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
No association between the frequency of ApoE-ɛ4 and the occurrence of depression was found in patients undergoing hemodialysis.
|
25707516 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59-0.99).
|
25979253 |
2015 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Potential confounders included in the analysis comprised age, sex, education, the Apolipoprotein E4 (ApoE4) allele status, polypharmacy, and the comorbidities depression, diabetes, ischemic heart disease, and stroke.
|
25341874 |
2015 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
This may explain conflicting results of previous studies where APOE ε4 status was not taken into account when exploring the relationship between depression and MCI.
|
23611364 |
2014 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E ε4 allele in nondemented elderly: a preliminary study.
|
24856546 |
2014 |
|
Mental Depression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression.
|
23171142 |
2013 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the roles of ApoE alleles and genotypes in dementia and cognitively impaired not demented (CIND), assessed the risk of co-existing or prior health conditions (i.e. depression), family history of diseases, and lifestyle factors on dementia, and explored the interactions between genetic and environmental risk factors and their joint effects on dementia and cognitive impairment.
|
23255503 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The FCs of the rLOD patients without APOE4 were significantly increased (p<0.05) in the resting state, but the rLOD patients who carried APOE4 showed a trend toward decreased FCs.
|
23270974 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multivariable analyses were adjusted for socio-demographic and vascular factors, cognitive impairment, and apolipoprotein E. Strong significant associations were found between all seven SNPs and DEP and, in particular, first-onset DEP in persons without a past history of depression (P-values ranging from 0.005 to 0.0004).
|
24193727 |
2013 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mean baseline age was 74.0 ± 3.0 years, 51 (5.2%) participants had depression, 545 (55.2%) were women, 531 (53.7%) were black, and 286 (30.7%) had one or more apolipoprotein E e4 allele.
|
22499763 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
ApoE4 is not associated with depression when mild cognitive impairment is considered.
|
22700491 |
2013 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Within LOD group there is no difference between those with and without ApoE4 accordingly in age of onset of depression, cognitive functions and severity of LOD.
|
22226379 |
2012 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While some studies failed to find a significant association between the APOE polymorphism and NPS in late-onset AD, other studies reported a significant association between the APOE ɛ4 allele and an increase in agitation/aggression, hallucinations, delusions, and late-life depression or anxiety.
|
21763789 |
2012 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PIF was associated with depression (OR 1.08, 95% CI 1.01 to 1.15; p<0.02) and was inversely associated with APOE ε4 (OR 0.21, 95% CI 0.05 to 0.87; p=0.03), again suggesting a protective effect.
|
20884673 |
2011 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There were synergistic interactions between depression and APOE e4 on incident dementia independent of covariates.
|
21845591 |
2011 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
the apolipoprotein E epsilon-4 (APOE [small element of] 4) allele and depression are independently associated with increased risk for cognitive decline (CD).
|
21218563 |
2011 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype was available in 153 patients, and in AD, but not in DLB, a general linear model showed that the presence of APOEε4 allele was significantly associated with depression (F = 4.14; p = 0.045).
|
21905099 |
2011 |