|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both ApoE4 carriers and non-ApoE4 carriers with depression had lower Abeta42 and a higher Abeta40/Abeta42 ratio in plasma compared with non-ApoE4 carriers without depression in the homebound elderly.
|
19812466 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Outpatients with AD (n = 40) were clinically evaluated for cognitive decline (MMSE) and psychiatric symptoms (Cornell Scale for Depression in Dementia; Neuropsychiatric Inventory) and genotyped for APOE variants.
|
19618379 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor.
|
20431431 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a significant positive correlation between gray matter volume of right medial frontal gyrus and Digit Span Test score in RLOD patients with ApoE epsilon4 allele carriers.
|
19647324 |
2010 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depression and APOE act independently to increase the risk for cognitive decline and may provide targets for prevention and early treatment.
|
20374396 |
2010 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, significant interaction was found between APOE-epsilon4 genotype and SMC on depression.
|
19494432 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No effect of APOE genotype on risk for depression was found.
|
18179845 |
2009 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, little research has investigated whether a history of depression influences the relationship between APOE epsilon4 and CD.
|
19155747 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE related hippocampal shape alteration in geriatric depression.
|
19010425 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated an apparent association between the APOE4 allele and depression in the combined dataset (p=0.001) when not controlling for cognitive status.
|
19368858 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between AD and/or depression to gene polymorphisms APO E (epsilon4), choline acetyltransferase (ChAT) 4G to A, serotonin-transporter gene promoter-length, dopamine-D4-receptor, ciliary-neurotrophic-factor-null mutation and brain-derived neurotrophic factor (C270T) and to various known factors were analyzed.
|
18603262 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors hypothesized that they might find a subtype of depression related to impaired cognitive performance associated with the APOE-epsilon4 allele.
|
19307863 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Depression is common in multiple sclerosis (MS) and the role of ApoE alleles is unknown.
|
19244396 |
2009 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The epsilon4 allele of the APOE gene has been linked with a number of neuropsychiatric illnesses, and also with stress and depression among geriatric populations.
|
18641859 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study.
|
18058831 |
2008 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evidence on apolipoprotein E (APOE) gene as a vulnerability factor for depression is mixed.
|
18843194 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Test scores were adjusted for age, sex, education, cerebrovascular disease, depression and APOE genotype and additionally for race.
|
17052804 |
2008 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interaction of depression and APOE epsilon4 was statistically significant in the analytical models.
|
18678795 |
2008 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ApoE4 allele is associated with late-life depression: a population-based study.
|
17911363 |
2007 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.
|
17623814 |
2007 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that smaller OFC volume would be associated with depression, greater hyperintense lesion volume and severity, and APOE epsilon4 or 5HTTLPR short allele carriers.
|
17335636 |
2007 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a synergistic interaction between depression and apolipoprotein E genotype.
|
16533972 |
2006 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the role of serotonin in depression, searching for association of two serotoninergic polymorphisms (T102C of serotonin receptor 5-HT2A and serotonin transporter linked polymorphic region -5-HTTLPR- of SLC6A4 gene) with depressive symptoms and considering their possible interactions with Apolipoprotein E (ApoE) and between themselves, in a sample of 208 sporadic AD patients and 116 normal controls from Italy.
|
17183148 |
2006 |
|
Mental Depression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The APOE genotype may contribute to cognitive performance and suicidality in geriatric depression, rather than being a specific risk factor for the disorder.
|
16954688 |
2006 |
|
Mental Depression
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is speculation these symptoms result from known genetic risk factors for AD, therefore we investigated the role of apolipoprotein E epsilon4 in the aetiology of depression in AD.
|
15627763 |
2005 |