|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Using molecular analysis, a loss of Wilms' tumor gene 1 (WT1) transcript and a biallelic expression of insulin growth factor 2 (IGF2) could be revealed.
|
16177880 |
2006 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This speculation was heightened by genetic evidence for the involvement of genomic imprinting in Beck-Wiedemann syndrome and Wilms' tumour, combined with the discovery that the IGF-II gene is imprinted.
|
9239720 |
1997 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results showed that all nine cases of CMN (classic, mixed, and cellular) contained abundant IGF2 but not WT1 transcripts.
|
8634785 |
1995 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF-II expression is activated in several types of human neoplasms and an alteration of IGF-II imprinting has been described in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
7981680 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the increased expression of IGF2 in Wilms' tumor may be caused either by biallelic gene expression in LOI tumors from promoters P2-P4 and/or by a reversion to an earlier stage of development which is characterized by increased synthesis of this fetal growth factor.
|
8621549 |
1996 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, loss of IGF2 imprinting has been reported in Wilms' tumor and in several other malignancies, and it has been suggested that biallelic expression of the gene leads to overexpression of IGF-II peptide and increased mitogenic activity.
|
7745016 |
1995 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor.
|
23074036 |
2013 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The level of IGF2 expression was comparable with that of Wilms tumor.
|
9385942 |
1997 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This contrasts the situation we found at the IGF2/H19 locus, which shows high overexpression of IGF2 and inversely correlated expression of the H19 gene in WT.
|
23825673 |
2013 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two other 11p15.5 loci, the linked and oppositely imprinted H19 and IGF2 genes, have been previously implicated in WT pathogenesis, and several of the tumors with persistent KIP2 mRNA expression and absence of KIP2 coding mutations showed full inactivation of H19.
|
9311733 |
1997 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues.
|
12702581 |
2003 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Structural alteration of the insulin-like growth factor II-gene in Wilms tumour.
|
2545450 |
1989 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
|
16518847 |
2006 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that underexpression, deletion, or mutation of WT1 may result in increased expression of the IGF-IR, whose activation by IGF-II may be an important aspect of the biology of Wilms tumor.
|
8390684 |
1993 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using eight 11p15 markers including HRAS1, INS and IGF2 we have studied eight sporadic and hereditary cases of BWS whether or not associated with a nephroblastoma.
|
2905880 |
1988 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.
|
2995818 |
1985 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in the onset of sporadic Wilms tumor and several other embryonal tumors.
|
9144243 |
1997 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT.
|
11431321 |
2001 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
|
1323141 |
1992 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have reported that the loss of the insulin-like growth factor-2 (IGF2) gene imprinting results in the deregulation of both IGF2 alleles, which may contribute to the onset of Wilms tumor.
|
8644850 |
1996 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This review summarises the critical discussion at an international workshop held under the auspices of The European Network for Cancer Research in Children and Adolescents (ENCCA) consortium, where the potential for drug development to target IGF2 and the WT epigenome was debated.
|
25478630 |
2014 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe a family with overgrowth in three generations and Wilms' tumor in two generations, with paternal inheritance of a cis-duplication at 11p15.5 spanning the BWS IC1 region and including H19, IGFII, INS, and TH.
|
17325026 |
2007 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression.
|
7535092 |
1995 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of single-strand conformation polymorphism (SSCP) and polymerase chain reaction (PCR) sequencing techniques, no mutations were identified in the WT1 tumour-suppressor gene from the 11p13 region, but a novel polymorphism was identified in exon 1. mRNA expression studies using the insulin-like growth factor II (IGF-II) gene, located in 11p15, showed that there was no relaxation of imprinting at this locus.
|
7911030 |
1994 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss of imprinting (LOI) of the IGF2 gene (which encodes insulin-like growth factor II) is the most common genetic or epigenetic alteration in Wilms tumor; LOI involves aberrant activation of the normally repressed maternally inherited allele.
|
17686827 |
2007 |