|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
|
1323141 |
1992 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Since continued expression of N-myc and IGF-II mRNAs is also a characteristic feature of Wilms' tumor, a childhood neoplasm of probable fetal kidney origin, we were particularly interested in the possibility that their expression might be linked or coordinately regulated in the developing kidney.
|
2537832 |
1989 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Structural alteration of the insulin-like growth factor II-gene in Wilms tumour.
|
2545450 |
1989 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
|
2554059 |
1989 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using eight 11p15 markers including HRAS1, INS and IGF2 we have studied eight sporadic and hereditary cases of BWS whether or not associated with a nephroblastoma.
|
2905880 |
1988 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings suggest that IGF-II may be involved in the aetiology of Wilms' tumour.
|
2995817 |
1985 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.
|
2995818 |
1985 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Therefore, IGFII overexpression in WT is most likely a tumour epiphenomenon.
|
3038359 |
1987 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor II messenger ribonucleic acid expression in Wilms tumor, nephrogenic rest, and kidney.
|
7504120 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Paediatric neoplasms, like Wilm's tumor (WT) and rhabdomyosarcoma, often express IGF2 and H19.
|
7527480 |
1994 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.
|
7534414 |
1995 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression.
|
7535092 |
1995 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Neuroblastoma, which is an embryonal tumor originating from neural crest-derived cells, occasionally occurs in individuals with the Beckwith-Wiedemann syndrome; Wilm's tumor and embryonal rhabdomyosarcoma occur even more frequently in the Beckwith-Wiedemann syndrome; and paternal uniparental disomy of H19 and IGF2 loci (chromosome 11p15) is present in the Beckwith-Wiedemann syndrome.
|
7614476 |
1995 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We show here, that in contrast to the situation in Wilms' tumor, H19 expression is not a prerequisite for maintaining a monoallelic IGF2 expression.
|
7624139 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This aberrant pattern of promoter imprinting, which was not detected in fetal kidney, provides further evidence that pathological relaxation of IGF2 imprinting is involved in the genesis of Wilms tumour.
|
7651739 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, loss of IGF2 imprinting has been reported in Wilms' tumor and in several other malignancies, and it has been suggested that biallelic expression of the gene leads to overexpression of IGF-II peptide and increased mitogenic activity.
|
7745016 |
1995 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This frequency suggests that < or = 25% of the cases of Wilms tumor are due to the failure to imprint the maternal Igf-2 gene.
|
7847379 |
1995 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
H19, a putative growth suppressor, is oppositely imprinted to the neighboring insulin-like growth factor II (IGF2) gene and an up-regulation of IGF2 expression has been linked previously to a down-regulation of H19 expression in the progression to Wilms' tumor.
|
7866996 |
1995 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of single-strand conformation polymorphism (SSCP) and polymerase chain reaction (PCR) sequencing techniques, no mutations were identified in the WT1 tumour-suppressor gene from the 11p13 region, but a novel polymorphism was identified in exon 1. mRNA expression studies using the insulin-like growth factor II (IGF-II) gene, located in 11p15, showed that there was no relaxation of imprinting at this locus.
|
7911030 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour.
|
7920665 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF-II expression is activated in several types of human neoplasms and an alteration of IGF-II imprinting has been described in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
7981680 |
1994 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
H19 (RNA transcripts) and IGF2 are manifested in Wilms' tumor, rhabdomyosarcoma, immature ovarian teratoma and gestational trophoblastic diseases.
|
8073225 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We report here that the IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically.
|
8097018 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A comparison of cultures derived from an epithelial-rich, classic Wilms' tumor and the anaplastic Wilm's tumor indicated that both lacked IGF-2 and WT-1 mRNA expression.
|
8178926 |
1994 |