|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.
|
2995818 |
1985 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings suggest that IGF-II may be involved in the aetiology of Wilms' tumour.
|
2995817 |
1985 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Therefore, IGFII overexpression in WT is most likely a tumour epiphenomenon.
|
3038359 |
1987 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using eight 11p15 markers including HRAS1, INS and IGF2 we have studied eight sporadic and hereditary cases of BWS whether or not associated with a nephroblastoma.
|
2905880 |
1988 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Structural alteration of the insulin-like growth factor II-gene in Wilms tumour.
|
2545450 |
1989 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilms' tumor.
|
2554059 |
1989 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Since continued expression of N-myc and IGF-II mRNAs is also a characteristic feature of Wilms' tumor, a childhood neoplasm of probable fetal kidney origin, we were particularly interested in the possibility that their expression might be linked or coordinately regulated in the developing kidney.
|
2537832 |
1989 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
|
1323141 |
1992 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that underexpression, deletion, or mutation of WT1 may result in increased expression of the IGF-IR, whose activation by IGF-II may be an important aspect of the biology of Wilms tumor.
|
8390684 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor II and WT1 transcript localization in human fetal kidney and Wilms' tumor.
|
8221652 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor II messenger ribonucleic acid expression in Wilms tumor, nephrogenic rest, and kidney.
|
7504120 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We report here that the IGF2 gene is expressed from the paternal allele in human fetal tissue, but that in Wilms' tumour expression can occur biallelically.
|
8097018 |
1993 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Detection of anti-sense transcripts of the insulin-like growth factor-2 gene in Wilms' tumor.
|
8256846 |
1993 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
But in one child who had generalized somatic overgrowth, IGF2 was transcribed from both alleles in her kidney, peripheral blood leukocytes and Wilms' tumour.
|
8298652 |
1993 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Constitutional loss of IGF2 imprinting in a subgroup of our BWS patients, and recent reports of loss of imprinting in sporadic Wilms tumour, further strengthens the view that IGF2 overexpression plays an important role in somatic overgrowth and the development of embryonal tumours.
|
8252039 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF-II expression is activated in several types of human neoplasms and an alteration of IGF-II imprinting has been described in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
7981680 |
1994 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of single-strand conformation polymorphism (SSCP) and polymerase chain reaction (PCR) sequencing techniques, no mutations were identified in the WT1 tumour-suppressor gene from the 11p13 region, but a novel polymorphism was identified in exon 1. mRNA expression studies using the insulin-like growth factor II (IGF-II) gene, located in 11p15, showed that there was no relaxation of imprinting at this locus.
|
7911030 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour.
|
7920665 |
1994 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
H19 (RNA transcripts) and IGF2 are manifested in Wilms' tumor, rhabdomyosarcoma, immature ovarian teratoma and gestational trophoblastic diseases.
|
8073225 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Paediatric neoplasms, like Wilm's tumor (WT) and rhabdomyosarcoma, often express IGF2 and H19.
|
7527480 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A comparison of cultures derived from an epithelial-rich, classic Wilms' tumor and the anaplastic Wilm's tumor indicated that both lacked IGF-2 and WT-1 mRNA expression.
|
8178926 |
1994 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results showed that all nine cases of CMN (classic, mixed, and cellular) contained abundant IGF2 but not WT1 transcripts.
|
8634785 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, loss of IGF2 imprinting has been reported in Wilms' tumor and in several other malignancies, and it has been suggested that biallelic expression of the gene leads to overexpression of IGF-II peptide and increased mitogenic activity.
|
7745016 |
1995 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression.
|
7535092 |
1995 |