|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Wilms' tumor (WT) is an embryonal renal malignancy, which overexpresses insulin-like growth factor II (IGF-II), a fetal mitogen.
|
9070652 |
1997 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.
|
2995818 |
1985 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor II messenger ribonucleic acid expression in Wilms tumor, nephrogenic rest, and kidney.
|
7504120 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF-II expression is activated in several types of human neoplasms and an alteration of IGF-II imprinting has been described in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
7981680 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor II and WT1 transcript localization in human fetal kidney and Wilms' tumor.
|
8221652 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A comparison of cultures derived from an epithelial-rich, classic Wilms' tumor and the anaplastic Wilm's tumor indicated that both lacked IGF-2 and WT-1 mRNA expression.
|
8178926 |
1994 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
|
16518847 |
2006 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
But in one child who had generalized somatic overgrowth, IGF2 was transcribed from both alleles in her kidney, peripheral blood leukocytes and Wilms' tumour.
|
8298652 |
1993 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
By contrast the expression of a third Wilms tumour-related gene, WT1, was completely uncorrelated to the expression of IGF-II and JIP.
|
20044608 |
2009 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Constitutional loss of IGF2 imprinting in a subgroup of our BWS patients, and recent reports of loss of imprinting in sporadic Wilms tumour, further strengthens the view that IGF2 overexpression plays an important role in somatic overgrowth and the development of embryonal tumours.
|
8252039 |
1993 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Detection of anti-sense transcripts of the insulin-like growth factor-2 gene in Wilms' tumor.
|
8256846 |
1993 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.
|
18245780 |
2008 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor.
|
23074036 |
2013 |
|
Nephroblastoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.
|
7534414 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Epigenetic changes occur frequently in Wilms' tumor (WT), especially loss of imprinting (LOI) of IGF2/H19 at 11p15.
|
18644976 |
2008 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours.
|
19596915 |
2009 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of the Wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet-derived growth factor A and insulin-like growth factor 2 expression.
|
7535092 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genomic imprinting of insulin-like growth factor 2 (IGF2) has been shown to play an important role in the development of Wilms' tumor and adult cancers including lung and esophageal cancer.
|
11053988 |
2000 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
H19 (RNA transcripts) and IGF2 are manifested in Wilms' tumor, rhabdomyosarcoma, immature ovarian teratoma and gestational trophoblastic diseases.
|
8073225 |
1994 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
H19, a putative growth suppressor, is oppositely imprinted to the neighboring insulin-like growth factor II (IGF2) gene and an up-regulation of IGF2 expression has been linked previously to a down-regulation of H19 expression in the progression to Wilms' tumor.
|
7866996 |
1995 |
|
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT.
|
11431321 |
2001 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues.
|
12702581 |
2003 |
|
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, the analysis of the expression of other 11p15 imprinted genes and kidney-developmentally regulated genes indicates that IGF2 overexpression, inappropriate coexpression of RET and GDNF and, in some cases, down-regulation of CDKN1C may also play an important role in the pathogenesis of WT.
|
10749116 |
2000 |
|
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
19293570 |
2009 |