|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adoptive transfer experiments of cytokine-deficient mast cells show that these cells, by producing interleukin-6 (IL-6) and interferon-gamma (IFN-gamma), contribute to mouse adipose tissue cysteine protease cathepsin expression, apoptosis and angiogenesis, thereby promoting diet-induced obesity and glucose intolerance.
|
19633655 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we found that mice with an inactivated gene encoding the IL-6Rα chain of the receptor for IL-6 in myeloid cells (Il6ra(Δmyel) mice) developed exaggerated deterioration of glucose homeostasis during diet-induced obesity, due to enhanced resistance to insulin.
|
24681566 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this cohort, mean (SD) habitual sleep duration based on self-report was 7.6 (1.6) h and mean sleep duration by polysomnography (PSG) on the night prior to blood sampling was 6.2 (1.3) h. After adjusting for obesity and apnea severity, each additional hour of habitual sleep duration was associated with an 8% increase in C-reactive protein (CRP) levels (P=0.004) and 7% increase in interleukin-6 (IL-6) levels (P=0.0003).
|
19238807 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population.
|
24395296 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005).
|
16029943 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, our studies reveal that IL-6 action in T cells through classical IL-6 signalling promotes inflammation and insulin resistance early during obesity development, which can be compensated for by enhanced IL-6 trans-signalling at later stages.
|
28466852 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast to TNF, plasma (rather than adipose) IL-6 demonstrated the strongest relationship with obesity and insulin resistance.
|
11287357 |
2001 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We identified the increase in reactive oxygen species in combination with obesity-associated low adiponectin and high glucose and interleukin-6 as cause of the decrease in IRAK3 in THP-1 cells in vitro.
|
22272346 |
2012 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multivariate linear regression analysis revealed that obesity is the dominant force, thus explaining 18% and 24% of the IL-6 or CRP levels, respectively, in PCOS women.
|
15080783 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The evolutive advantages of increased inflammatory responses, hypersecretion of proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-18], or decreased anti-inflammatory molecules (adiponectin, certain TNF-alpha isoforms, soluble CD14, etc.), would lead in westernized countries to chronic inflammation conditions, such as obesity and type 2 diabetes, resulting in cardiovascular disease.
|
16472051 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-6 is a known regulator of adipose homeostasis in obesity and has been shown to be increased in primary and secondary models of lymphedema.
|
24633552 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Haptoglobin 2-2 genotype is associated with TNF- α and IL-6 levels in subjects with obesity.
|
24868113 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
During the expansion of adipose tissue mass in obesity there is a major inflammatory response in the tissue with increased expression and release of inflammation-related adipokines, including IL-6, leptin, monocyte chemoattractant protein-1 and TNF-alpha, together with decreased adiponectin production.
|
18397542 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dysregulation of several adipokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and adiponectin, contributes to the low-grade inflammation that is a hallmark of obesity.
|
21224869 |
2011 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In view of the increase in plasma concentrations of proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) in obesity, we investigated whether peripheral blood mononuclear cells (MNC) from obese subjects are in a proinflammatory state.
|
15364812 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results showed that mulberry leaf powder contains tricetin, gallic acid, chlorogenic acid, and other drug components that can regulate tumor necrosis factor (TNF), peroxisome proliferator-activated receptor gamma (PPARG), glycogen synthase kinase-3 beta (GSK3B), insulin receptor substrate 1 (IRS1), interleukin 6 (IL-6) and other proteins, which are related to the insulin and inflammatory signaling pathways, glucose metabolism and other related pathways, chronic inflammatory diseases, obesity, diabetic nephropathy, non-insulin-dependent diabetes mellitus and other diseases.
|
29782863 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we therefore focused on dietary composition as a specific trait related to obesity and we determined whether genetic variations in leptin (LEP), LEP receptor (LEPR), adiponectin (ADIPOQ), IL-6 and pro-opiomelanocortin (POMC) underlie specific native food preferences and obesity-related anthropometric parameters.
|
19747414 |
2010 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Composite genotype or haplotype analyses of all 3 IL6 promoter variants showed associations with type 2 diabetes (p<0.002), obesity (p<0.02), and the metabolic syndrome (p<0.01).
|
15645209 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT.
|
27083404 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition to a diet-induced obesity model, we also examined the role of adipocyte-derived IL-6 in a genetic model of obesity and insulin resistance by crossing the AdipoIL-6<sup>-/-</sup> mice with leptin-deficient (<i>ob/ob</i>) mice.
|
31386565 |
2019 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Higher rates of esophageal cancer cases may be attributed to lifestyle factors such as: diet, obesity, alcohol and tobacco use.Moreover, the presence of oral <i>P. gingivalis</i> and <i>T. forsythia</i> has been found to be associated with an increased risk of esophageal cancer.Our review describes the role of <i>P. gingivalis</i> and <i>T. forsythia</i> in signaling pathways responsible for cancer development.It has been shown that <i>T. forsythia</i> may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α.Moreover, gingipain K produced by <i>P. gingivalis,</i> affects hosts immune system by degradation of immunoglobulins and complement system (C3 and C5 components).
|
30728854 |
2019 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
S100A8/A9 (Calprotectin), Interleukin-6, and C-Reactive Protein in Obesity and Diabetes before and after Roux-en-Y Gastric Bypass Surgery.
|
28848164 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
CVD and cancer share risk factors such as obesity and diabetes mellitus and have common diagnostic biomarkers such as interleukin-6 and C-reactive protein.
|
29258216 |
2017 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the pathophysiology of various human diseases such as type 2 diabetes and obesity.
|
15561970 |
2004 |