|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study examined the potential association of IL-6-174 G/C polymorphism, together with obesity and smoking, with the presence of CVD in RA patients.
|
18848327 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In G/G population, the IL-6 plasma level of NWO and OB was significantly higher with respect to NW.
|
18991689 |
2008 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, independent of obesity.
|
19125180 |
2008 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this cohort, mean (SD) habitual sleep duration based on self-report was 7.6 (1.6) h and mean sleep duration by polysomnography (PSG) on the night prior to blood sampling was 6.2 (1.3) h. After adjusting for obesity and apnea severity, each additional hour of habitual sleep duration was associated with an 8% increase in C-reactive protein (CRP) levels (P=0.004) and 7% increase in interleukin-6 (IL-6) levels (P=0.0003).
|
19238807 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity.
|
19240255 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Given the association between obesity, chronic low-grade inflammation, and insulin resistance, we examined the effects of alpha- and gamma-MG on markers of inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes treated with lipopolysaccharide (LPS). alpha- and gamma-MG decreased the induction by LPS of inflammatory genes, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant protein-1, and Toll-like receptor-2.
|
19403722 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of IL-6 increase with obesity and insulin resistance.
|
19428338 |
2009 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adoptive transfer experiments of cytokine-deficient mast cells show that these cells, by producing interleukin-6 (IL-6) and interferon-gamma (IFN-gamma), contribute to mouse adipose tissue cysteine protease cathepsin expression, apoptosis and angiogenesis, thereby promoting diet-induced obesity and glucose intolerance.
|
19633655 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results from whole genome and candidate gene studies support the potential role of NR1H4, SIRT1, SMARCA2 and IL6 in obesity.
|
19652658 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we therefore focused on dietary composition as a specific trait related to obesity and we determined whether genetic variations in leptin (LEP), LEP receptor (LEPR), adiponectin (ADIPOQ), IL-6 and pro-opiomelanocortin (POMC) underlie specific native food preferences and obesity-related anthropometric parameters.
|
19747414 |
2010 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
SNPs IL6 -174G/C and TNFalpha -308G/A are not major contributors to T2D or obesity risk in our Tunisian population.
|
20132806 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
The chronic inflammatory response caused by obesity and enhanced production of IL-6 and TNF may also increase the risk of other cancers.
|
20141834 |
2010 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found a relation between G174C polymorphism in IL-6 gene and G308A in TNF-alpha gene with the occurrence of obesity.
|
20156727 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism 174G>C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.
|
20156756 |
2009 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the promoter region of the IL6 gene (-174G/C), has been previously reported to be involved in obesity and metabolic syndrome development.
|
20358354 |
2009 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines such as interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNFalpha) are produced by human adipose tissue dependent on the degree of obesity.
|
20660075 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we analyze the current knowledge about the potential contribution that expanding adipose tissue in obesity could make to the development of cancer via dysregulated secretion of pro-inflammatory cytokines, chemokines and adipokines such as TNF-α, IL-6, leptin, adiponectin, visfatin and PAI-1.
|
21111705 |
2011 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism found in point 174 (G174C) of a promoter region of IL-6 gene affects the level of interleukin-6 expression and, consequently, may lead to obesity and correlated conditions.
|
21147639 |
2010 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dysregulation of several adipokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and adiponectin, contributes to the low-grade inflammation that is a hallmark of obesity.
|
21224869 |
2011 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our findings show that although pre-gravid obesity was associated with greater expression of placental pro-inflammatory cytokines and higher circulating IL-6 in pregnancy, there were no major differences in immune cell populations within the placental villi and only a greater degree of muscularity in the vessel walls.
|
21232790 |
2011 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The IL-6 G174C polymorphism was also associated obesity when using allelic comparisons, the recessive genetic model and the dominant genetic model with OR (95% CI) of 1.95 (1.37-2.77), 1.44 (1.15-1.80), and 1.36 (1.16-1.59), respectively.
|
21660081 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets.
|
21826222 |
2011 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6).
|
22037645 |
2011 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data show that the G allele of the -174G/C IL-6 polymorphism and obesity can be considered as risk factors for the prognosis and management of psoriasis.
|
22158445 |
2012 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common variants of IL6, LEPR, and PBEF1 are associated with obesity in Indian children.
|
22228719 |
2012 |